Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation

Tadashi Goto, Haruhiko Yoshida, Ryosuke Tateishi, Kenichiro Enooku, Eriko Goto, Takahisa Sato, Takamasa Ohki, Ryota Masuzaki, Jun Imamura, Shuichiro Shiina, Kazuhiko Koike, Masao Omata

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background: High serum load of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) is a strong risk factor of hepatocellular carcinoma (HCC) development, independent of hepatitis B e antigen, serum alanine aminotransferase level, and liver cirrhosis. We evaluated whether serum HBV DNA load is associated with the risk of recurrence of HBV-related HCC treated with radiofrequency ablation (RFA). Methods The study population was 69 consecutive patients with HBV-related HCC treated locally completely with RFA between January 2000 and September 2007. The risk factors for HCC recurrence were analyzed based on laboratory data, including serum HBV DNA load, together with tumor size and number using univariate and multivariate proportional hazard regression analyses. Results: HCC recurrence was observed in 42 of 69 patients during the median observation period of 1.5 years. Cumulative recurrence rates at 1, 3, and 5 years were 26.5, 57.8, and 74.3%, respectively. In univariate analysis, albumin (<3.5 g/dl), platelet count (<150 × 10 3/mm3), prothrombin activity (PT) (<70%), Child-Pugh class B, serum HBV DNA load ([4.0 log10 copies/ml), and tumor number ([3) were associated with the recurrence at p ≤ 0.15. Multivariate Cox regression analysis with stepwise variable selection showed that the tumor number (risk ratio, 4.63; 95% CI, 1.50-14.25, P = 0.0076), low PT (3.39, 1.52-5.78, P = 0.0029), and high HBV DNA load (2.67, 1.16-6.14, P = 0.021) were independent risk factors for HCC recurrence. Conclusion Serum HBV DNA load is associated with the risk of recurrence of HBV-related HCC after RFA.

Original languageEnglish
Pages (from-to)767-773
Number of pages7
JournalHepatology International
Volume5
Issue number3
DOIs
Publication statusPublished - Sept 2011
Externally publishedYes

Keywords

  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Radiofrequency ablation
  • Recurrence

Fingerprint

Dive into the research topics of 'Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation'. Together they form a unique fingerprint.

Cite this