TY - JOUR
T1 - INFLUENCE OF FOVEAL GLIAL TISSUE AFTER MACULAR HOLE SURGERY ON OUTER RETINAL RESTORATION AND VISUAL ACUITY
AU - Iwasaki, Masanori
AU - Nakashizuka, Hiroyuki
AU - Tanaka, Koji
AU - Wakatsuki, Yu
AU - Onoe, Hajime
AU - Nakagawa, Naoya
AU - Fujimiya, Taishi
AU - Koutari, Sawako
AU - Sakakibara, Takuya
AU - Shoda, Chiho
AU - Hanaguri, Junya
AU - Yokota, Harumasa
AU - Takayuki, Hattori
AU - Mori, Ryusaburo
AU - Shimada, Hiroyuki
AU - Nagaoka, Taiji
AU - Yamagami, Satoru
N1 - Publisher Copyright:
Copyright © 2024 by Ophthalmic Communications Society, Inc.
PY - 2025/2/1
Y1 - 2025/2/1
N2 - Purpose: To investigate the impact of foveal glial tissue on the anatomical and functional results after macular hole (MH) surgery. Methods: This study included 141 consecutive eyes that underwent successful vitrectomy for full-thickness MH between January 2015 and December 2022. The best-corrected visual acuity and the length of outer retinal defects were evaluated preoperatively and at 6 months postoperatively. Macular hole with retinal detachment, recurrent MH, and traumatic MH were excluded. Multiple regression analyses were conducted on outer retinal restoration and visual acuity using foveal glial tissue size, surgical technique of internal limiting membrane peeling or inverted internal limiting membrane flap, and high myopia as explanatory variables. Results: Analyses revealed that the foveal glial tissue significantly limited the outer nuclear layer, external limiting membrane restoration, and ellipsoid zone restoration as well as best-corrected visual acuity improvement (r = -0.380, P < 0.001; r = -0.314, P = 0.035; r = -0.530, P = 0.015; r = -0.00027, P = 0.001; respectively). Meanwhile, the surgical technique and high myopia did not significantly affect the restoration of outer nuclear layer, external limiting membrane, ellipsoid zone, and best-corrected visual acuity after surgery. Conclusion: Foveal glial tissue after MH surgery attenuated outer nuclear layer, external limiting membrane, and ellipsoid zone restoration as well as best-corrected visual acuity improvement.
AB - Purpose: To investigate the impact of foveal glial tissue on the anatomical and functional results after macular hole (MH) surgery. Methods: This study included 141 consecutive eyes that underwent successful vitrectomy for full-thickness MH between January 2015 and December 2022. The best-corrected visual acuity and the length of outer retinal defects were evaluated preoperatively and at 6 months postoperatively. Macular hole with retinal detachment, recurrent MH, and traumatic MH were excluded. Multiple regression analyses were conducted on outer retinal restoration and visual acuity using foveal glial tissue size, surgical technique of internal limiting membrane peeling or inverted internal limiting membrane flap, and high myopia as explanatory variables. Results: Analyses revealed that the foveal glial tissue significantly limited the outer nuclear layer, external limiting membrane restoration, and ellipsoid zone restoration as well as best-corrected visual acuity improvement (r = -0.380, P < 0.001; r = -0.314, P = 0.035; r = -0.530, P = 0.015; r = -0.00027, P = 0.001; respectively). Meanwhile, the surgical technique and high myopia did not significantly affect the restoration of outer nuclear layer, external limiting membrane, ellipsoid zone, and best-corrected visual acuity after surgery. Conclusion: Foveal glial tissue after MH surgery attenuated outer nuclear layer, external limiting membrane, and ellipsoid zone restoration as well as best-corrected visual acuity improvement.
KW - conventional peeling
KW - foveal glial tissue
KW - high myopia
KW - inverted internal limiting membrane flap technique
KW - macular hole surgery
KW - outer retinal restoration
KW - spectral domain optical coherence tomography
KW - vitrectomy
UR - http://www.scopus.com/inward/record.url?scp=85208037138&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000004294
DO - 10.1097/IAE.0000000000004294
M3 - Article
C2 - 39733283
AN - SCOPUS:85208037138
SN - 0275-004X
VL - 45
SP - 215
EP - 221
JO - Retina
JF - Retina
IS - 2
ER -