Abstract
We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine (Trp/Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography (HPLC). The survival rate after recurrence was higher in the local recurrence group (n = 1l) than in the distant metastases group (n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 1304-1306 |
| Number of pages | 3 |
| Journal | Japanese Journal of Cancer and Chemotherapy |
| Volume | 41 |
| Issue number | 10 |
| Publication status | Published - 1 Oct 2014 |
Keywords
- 3-dioxygenase (IDO)
- Breast cancer
- Indoleamine 2
- Metastases
