Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases

Kenichi Sakurai; Shigeru Fujisaki; Shuhei Suzuki; Saki Nagashima; Tetsuyo Maeda; Ryouichi Tomita; Yukiko Hara; Tomohiro Hirano; Katsuhisa Enomoto; Sadao Amano

Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases

Kenichi Sakurai, Shigeru Fujisaki, Shuhei Suzuki, Saki Nagashima, Tetsuyo Maeda, Ryouichi Tomita, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Sadao Amano

School of Medicine

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine (Trp/Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography (HPLC). The survival rate after recurrence was higher in the local recurrence group (n = 1l) than in the distant metastases group (n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.

Original language	English
Pages (from-to)	1304-1306
Number of pages	3
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	41
Issue number	10
Publication status	Published - 1 Oct 2014

Keywords

3-dioxygenase (IDO)
Breast cancer
Indoleamine 2
Metastases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{dbb7790546a342bb9af2e50b082e5024,

title = "Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases",

abstract = "We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine (Trp/Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography (HPLC). The survival rate after recurrence was higher in the local recurrence group (n = 1l) than in the distant metastases group (n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.",

keywords = "3-dioxygenase (IDO), Breast cancer, Indoleamine 2, Metastases",

author = "Kenichi Sakurai and Shigeru Fujisaki and Shuhei Suzuki and Saki Nagashima and Tetsuyo Maeda and Ryouichi Tomita and Yukiko Hara and Tomohiro Hirano and Katsuhisa Enomoto and Sadao Amano",

year = "2014",

month = oct,

day = "1",

language = "English",

volume = "41",

pages = "1304--1306",

journal = "Japanese Journal of Cancer and Chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

number = "10",

}

TY - JOUR

T1 - Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases

AU - Sakurai, Kenichi

AU - Fujisaki, Shigeru

AU - Suzuki, Shuhei

AU - Nagashima, Saki

AU - Maeda, Tetsuyo

AU - Tomita, Ryouichi

AU - Hara, Yukiko

AU - Hirano, Tomohiro

AU - Enomoto, Katsuhisa

AU - Amano, Sadao

PY - 2014/10/1

Y1 - 2014/10/1

N2 - We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine (Trp/Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography (HPLC). The survival rate after recurrence was higher in the local recurrence group (n = 1l) than in the distant metastases group (n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.

AB - We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine (Trp/Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography (HPLC). The survival rate after recurrence was higher in the local recurrence group (n = 1l) than in the distant metastases group (n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.

KW - 3-dioxygenase (IDO)

KW - Breast cancer

KW - Indoleamine 2

KW - Metastases

UR - http://www.scopus.com/inward/record.url?scp=84923381329&partnerID=8YFLogxK

M3 - Review article

C2 - 25335725

AN - SCOPUS:84923381329

SN - 0385-0684

VL - 41

SP - 1304

EP - 1306

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 10

ER -

Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases

Abstract

Keywords

UN SDGs

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