Indoleamine 2,3-dioxygenase activity during I131-radioisotope therapy for metastatic thyroid cancer

Kenichi Sakurai; Shigeru Fujisaki; Keita Adachi; Shuhel Suzuki; Yuki Masuo; Saki Nagashima; Yukiko Hara; Ryouichi Tomita; Kenji Gonda; Tomohiro Hirano; Katsuhisa Enomoto

Indoleamine 2,3-dioxygenase activity during I¹³¹-radioisotope therapy for metastatic thyroid cancer

Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhel Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Ryouichi Tomita, Kenji Gonda, Tomohiro Hirano, Katsuhisa Enomoto

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDa) during I¹³¹-radioisotope therapy for metastatic thyroid cancer. The IDO activity can be measured by the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by using high performance liquid chromatography (HPLC). The serum Trp/Kyn levels of were lower in thyroid cancer patients with lung metastases than in patients without metastases. The IDO activity increased after the development of lung metastases from thyroid cancer. The DO activity was correlated with the number of metastatic lesions during I¹³¹-radio- isotope therapy. These results suggest that measurement of the Trp/Kyn ratio is useful in the evaluation of the immunological metastatic status during I¹³¹-radioisotope therapy.

Original language	English
Pages (from-to)	1259-1261
Number of pages	3
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	42
Issue number	10
Publication status	Published - Oct 2015

Keywords

I-ra-dioisotope therapy
Indoleamine 2,3-dioxygenase (IDa)
Thyroid cancer

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title = "Indoleamine 2,3-dioxygenase activity during I131-radioisotope therapy for metastatic thyroid cancer",

abstract = "We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDa) during I131-radioisotope therapy for metastatic thyroid cancer. The IDO activity can be measured by the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by using high performance liquid chromatography (HPLC). The serum Trp/Kyn levels of were lower in thyroid cancer patients with lung metastases than in patients without metastases. The IDO activity increased after the development of lung metastases from thyroid cancer. The DO activity was correlated with the number of metastatic lesions during I131-radio- isotope therapy. These results suggest that measurement of the Trp/Kyn ratio is useful in the evaluation of the immunological metastatic status during I131-radioisotope therapy.",

keywords = "I-ra-dioisotope therapy, Indoleamine 2,3-dioxygenase (IDa), Thyroid cancer",

author = "Kenichi Sakurai and Shigeru Fujisaki and Keita Adachi and Shuhel Suzuki and Yuki Masuo and Saki Nagashima and Yukiko Hara and Ryouichi Tomita and Kenji Gonda and Tomohiro Hirano and Katsuhisa Enomoto",

year = "2015",

month = oct,

language = "English",

volume = "42",

pages = "1259--1261",

journal = "Japanese Journal of Cancer and Chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

number = "10",

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TY - JOUR

T1 - Indoleamine 2,3-dioxygenase activity during I131-radioisotope therapy for metastatic thyroid cancer

AU - Sakurai, Kenichi

AU - Fujisaki, Shigeru

AU - Adachi, Keita

AU - Suzuki, Shuhel

AU - Masuo, Yuki

AU - Nagashima, Saki

AU - Hara, Yukiko

AU - Tomita, Ryouichi

AU - Gonda, Kenji

AU - Hirano, Tomohiro

AU - Enomoto, Katsuhisa

PY - 2015/10

Y1 - 2015/10

N2 - We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDa) during I131-radioisotope therapy for metastatic thyroid cancer. The IDO activity can be measured by the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by using high performance liquid chromatography (HPLC). The serum Trp/Kyn levels of were lower in thyroid cancer patients with lung metastases than in patients without metastases. The IDO activity increased after the development of lung metastases from thyroid cancer. The DO activity was correlated with the number of metastatic lesions during I131-radio- isotope therapy. These results suggest that measurement of the Trp/Kyn ratio is useful in the evaluation of the immunological metastatic status during I131-radioisotope therapy.

AB - We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDa) during I131-radioisotope therapy for metastatic thyroid cancer. The IDO activity can be measured by the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by using high performance liquid chromatography (HPLC). The serum Trp/Kyn levels of were lower in thyroid cancer patients with lung metastases than in patients without metastases. The IDO activity increased after the development of lung metastases from thyroid cancer. The DO activity was correlated with the number of metastatic lesions during I131-radio- isotope therapy. These results suggest that measurement of the Trp/Kyn ratio is useful in the evaluation of the immunological metastatic status during I131-radioisotope therapy.

KW - I-ra-dioisotope therapy

KW - Indoleamine 2,3-dioxygenase (IDa)

KW - Thyroid cancer

UR - http://www.scopus.com/inward/record.url?scp=84962258900&partnerID=8YFLogxK

M3 - Article

C2 - 26489565

AN - SCOPUS:84962258900

SN - 0385-0684

VL - 42

SP - 1259

EP - 1261

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 10

ER -

Indoleamine 2,3-dioxygenase activity during I¹³¹-radioisotope therapy for metastatic thyroid cancer

Abstract

Keywords

UN SDGs

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