Indoleamine 2,3-Dioxygenase activity during fulvestrant therapy for multiple metastatic breast cancer patients

Kenichi Sakurai; Shigeru Fujisaki; Keita Adachi; Shuhei Suzuki; Yuki Masuo; Saki Nagashima; Yukiko Hara; Tomohiro Hirano; Katsuhisa Enomoto; Ryouichi Tomita; Kenji Gonda

Indoleamine 2,3-Dioxygenase activity during fulvestrant therapy for multiple metastatic breast cancer patients

Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Ryouichi Tomita, Kenji Gonda

School of Medicine

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDO) during fulvestrant therapy for multiple metastatic breast cancer patients. IDO activity can be measured using the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured using high-performance liquid chromatography (HPLC). The serum Trp/Kyn level in patients with multiple metastatic breast cancer was lower than in patients without metastases. IDO activity increased after breast cancer metastases developed. IDO activity was correlated with the number of metastatic lesions during toremifene and fulvestrant therapy. These results suggested that measurement of the Trp/Kyn ratio is useful to evaluate immunological metastatic status during endocrine therapy.

Original language	English
Pages (from-to)	1233-1236
Number of pages	4
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	43
Issue number	10
Publication status	Published - Oct 2016

Keywords

3-dioxygenase (IDO)
Breast cancer
Fulvestrant therapy
Indoleamine 2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Indoleamine 2,3-Dioxygenase activity during fulvestrant therapy for multiple metastatic breast cancer patients",

abstract = "We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDO) during fulvestrant therapy for multiple metastatic breast cancer patients. IDO activity can be measured using the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured using high-performance liquid chromatography (HPLC). The serum Trp/Kyn level in patients with multiple metastatic breast cancer was lower than in patients without metastases. IDO activity increased after breast cancer metastases developed. IDO activity was correlated with the number of metastatic lesions during toremifene and fulvestrant therapy. These results suggested that measurement of the Trp/Kyn ratio is useful to evaluate immunological metastatic status during endocrine therapy.",

keywords = "3-dioxygenase (IDO), Breast cancer, Fulvestrant therapy, Indoleamine 2",

author = "Kenichi Sakurai and Shigeru Fujisaki and Keita Adachi and Shuhei Suzuki and Yuki Masuo and Saki Nagashima and Yukiko Hara and Tomohiro Hirano and Katsuhisa Enomoto and Ryouichi Tomita and Kenji Gonda",

year = "2016",

month = oct,

language = "English",

volume = "43",

pages = "1233--1236",

journal = "Japanese Journal of Cancer and Chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

number = "10",

}

TY - JOUR

T1 - Indoleamine 2,3-Dioxygenase activity during fulvestrant therapy for multiple metastatic breast cancer patients

AU - Sakurai, Kenichi

AU - Fujisaki, Shigeru

AU - Adachi, Keita

AU - Suzuki, Shuhei

AU - Masuo, Yuki

AU - Nagashima, Saki

AU - Hara, Yukiko

AU - Hirano, Tomohiro

AU - Enomoto, Katsuhisa

AU - Tomita, Ryouichi

AU - Gonda, Kenji

PY - 2016/10

Y1 - 2016/10

N2 - We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDO) during fulvestrant therapy for multiple metastatic breast cancer patients. IDO activity can be measured using the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured using high-performance liquid chromatography (HPLC). The serum Trp/Kyn level in patients with multiple metastatic breast cancer was lower than in patients without metastases. IDO activity increased after breast cancer metastases developed. IDO activity was correlated with the number of metastatic lesions during toremifene and fulvestrant therapy. These results suggested that measurement of the Trp/Kyn ratio is useful to evaluate immunological metastatic status during endocrine therapy.

AB - We evaluated the clinical significance of indoleamine 2,3-dioxygenase (IDO) during fulvestrant therapy for multiple metastatic breast cancer patients. IDO activity can be measured using the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured using high-performance liquid chromatography (HPLC). The serum Trp/Kyn level in patients with multiple metastatic breast cancer was lower than in patients without metastases. IDO activity increased after breast cancer metastases developed. IDO activity was correlated with the number of metastatic lesions during toremifene and fulvestrant therapy. These results suggested that measurement of the Trp/Kyn ratio is useful to evaluate immunological metastatic status during endocrine therapy.

KW - 3-dioxygenase (IDO)

KW - Breast cancer

KW - Fulvestrant therapy

KW - Indoleamine 2

UR - http://www.scopus.com/inward/record.url?scp=85011076302&partnerID=8YFLogxK

M3 - Review article

C2 - 27760945

AN - SCOPUS:85011076302

SN - 0385-0684

VL - 43

SP - 1233

EP - 1236

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 10

ER -

Indoleamine 2,3-Dioxygenase activity during fulvestrant therapy for multiple metastatic breast cancer patients

Abstract

Keywords

UN SDGs

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