Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer

Kenichi Sakurai; Sadanori Matsuo; Katsuhisa Enomoto; Mayumi Tani; Akira Kitajima; Sadao Amano

Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer

Kenichi Sakurai, Sadanori Matsuo, Katsuhisa Enomoto, Mayumi Tani, Akira Kitajima, Sadao Amano

School of Medicine

Nihon University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in recurrent breast cancer during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations among age and Trp/Kyn ratio or immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. In under 35-year-old patients, there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio. But in over 36-year-old patients, both Trp/Kyn ratio and IAP value in post-chemotherapy were higher than in pre-chemotherapy. These results suggest that the immunological damages for the patients during chemotherapy may depend on the age of patients.

Original language	English
Pages (from-to)	1991-1993
Number of pages	3
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	36
Issue number	12
Publication status	Published - Nov 2009

Keywords

Breast cancer
Immunosuppressive acidic protein (IAP)
Indoleamine 2,3-dioxygenase (IDO)

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Cite this

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title = "Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer",

abstract = "We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in recurrent breast cancer during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations among age and Trp/Kyn ratio or immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. In under 35-year-old patients, there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio. But in over 36-year-old patients, both Trp/Kyn ratio and IAP value in post-chemotherapy were higher than in pre-chemotherapy. These results suggest that the immunological damages for the patients during chemotherapy may depend on the age of patients.",

keywords = "Breast cancer, Immunosuppressive acidic protein (IAP), Indoleamine 2,3-dioxygenase (IDO)",

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year = "2009",

month = nov,

language = "English",

volume = "36",

pages = "1991--1993",

journal = "Japanese Journal of Cancer and Chemotherapy",

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}

TY - JOUR

T1 - Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer

AU - Sakurai, Kenichi

AU - Matsuo, Sadanori

AU - Enomoto, Katsuhisa

AU - Tani, Mayumi

AU - Kitajima, Akira

AU - Amano, Sadao

PY - 2009/11

Y1 - 2009/11

N2 - We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in recurrent breast cancer during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations among age and Trp/Kyn ratio or immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. In under 35-year-old patients, there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio. But in over 36-year-old patients, both Trp/Kyn ratio and IAP value in post-chemotherapy were higher than in pre-chemotherapy. These results suggest that the immunological damages for the patients during chemotherapy may depend on the age of patients.

AB - We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in recurrent breast cancer during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations among age and Trp/Kyn ratio or immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. In under 35-year-old patients, there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio. But in over 36-year-old patients, both Trp/Kyn ratio and IAP value in post-chemotherapy were higher than in pre-chemotherapy. These results suggest that the immunological damages for the patients during chemotherapy may depend on the age of patients.

KW - Breast cancer

KW - Immunosuppressive acidic protein (IAP)

KW - Indoleamine 2,3-dioxygenase (IDO)

UR - http://www.scopus.com/inward/record.url?scp=84864579022&partnerID=8YFLogxK

M3 - Article

C2 - 20037301

AN - SCOPUS:84864579022

SN - 0385-0684

VL - 36

SP - 1991

EP - 1993

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 12

ER -

Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer

Abstract

Keywords

UN SDGs

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