[Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].

Kenichi Sakurai; Shigeru Fujisaki; Saki Nagashima; Tetsuyo Maeda; Ryouichi Tomita; Shuhei Suzuki; Yukiko Hara; Tomohiro Hirano; Katsuhisa Enomoto; Sadao Amano

[Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].

Kenichi Sakurai, Shigeru Fujisaki, Saki Nagashima, Tetsuyo Maeda, Ryouichi Tomita, Shuhei Suzuki, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Sadao Amano

School of Medicine

Nihon University

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in breast cancer patients during neoadjuvant chemotherapy. IDO activity can be determined by the tryptophan( Trp)/kynurenine( Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations between the Trp/Kyn ratios in the pre-chemotherapy, post-chemotherapy, and post-surgery phases of treatment and the effects of chemotherapy were studied. The Trp/ Kyn ratios were significantly lower in the post-epirubicin and cyclophosphamide( EC) chemotherapy phase and post- weekly paclitaxel( wPac) chemotherapy phase than in the pre-chemotherapy phase and post-chemotherapy phase, respectively. There was no significant correlation between the Trp/Kyn ratio in any phase and the response rate. These results suggest that measurement of the Trp/Kyn ratio is not useful for predicting the rate of response to chemotherapy in patients with breast cancer.

Original language	English
Pages (from-to)	1578-1580
Number of pages	3
Journal	Unknown Journal
Volume	40
Issue number	12
Publication status	Published - Nov 2013

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title = "[Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].",

abstract = "We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in breast cancer patients during neoadjuvant chemotherapy. IDO activity can be determined by the tryptophan( Trp)/kynurenine( Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations between the Trp/Kyn ratios in the pre-chemotherapy, post-chemotherapy, and post-surgery phases of treatment and the effects of chemotherapy were studied. The Trp/ Kyn ratios were significantly lower in the post-epirubicin and cyclophosphamide( EC) chemotherapy phase and post- weekly paclitaxel( wPac) chemotherapy phase than in the pre-chemotherapy phase and post-chemotherapy phase, respectively. There was no significant correlation between the Trp/Kyn ratio in any phase and the response rate. These results suggest that measurement of the Trp/Kyn ratio is not useful for predicting the rate of response to chemotherapy in patients with breast cancer.",

author = "Kenichi Sakurai and Shigeru Fujisaki and Saki Nagashima and Tetsuyo Maeda and Ryouichi Tomita and Shuhei Suzuki and Yukiko Hara and Tomohiro Hirano and Katsuhisa Enomoto and Sadao Amano",

year = "2013",

month = nov,

language = "English",

volume = "40",

pages = "1578--1580",

journal = "Unknown Journal",

number = "12",

}

TY - JOUR

T1 - [Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].

AU - Sakurai, Kenichi

AU - Fujisaki, Shigeru

AU - Nagashima, Saki

AU - Maeda, Tetsuyo

AU - Tomita, Ryouichi

AU - Suzuki, Shuhei

AU - Hara, Yukiko

AU - Hirano, Tomohiro

AU - Enomoto, Katsuhisa

AU - Amano, Sadao

PY - 2013/11

Y1 - 2013/11

N2 - We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in breast cancer patients during neoadjuvant chemotherapy. IDO activity can be determined by the tryptophan( Trp)/kynurenine( Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations between the Trp/Kyn ratios in the pre-chemotherapy, post-chemotherapy, and post-surgery phases of treatment and the effects of chemotherapy were studied. The Trp/ Kyn ratios were significantly lower in the post-epirubicin and cyclophosphamide( EC) chemotherapy phase and post- weekly paclitaxel( wPac) chemotherapy phase than in the pre-chemotherapy phase and post-chemotherapy phase, respectively. There was no significant correlation between the Trp/Kyn ratio in any phase and the response rate. These results suggest that measurement of the Trp/Kyn ratio is not useful for predicting the rate of response to chemotherapy in patients with breast cancer.

AB - We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in breast cancer patients during neoadjuvant chemotherapy. IDO activity can be determined by the tryptophan( Trp)/kynurenine( Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations between the Trp/Kyn ratios in the pre-chemotherapy, post-chemotherapy, and post-surgery phases of treatment and the effects of chemotherapy were studied. The Trp/ Kyn ratios were significantly lower in the post-epirubicin and cyclophosphamide( EC) chemotherapy phase and post- weekly paclitaxel( wPac) chemotherapy phase than in the pre-chemotherapy phase and post-chemotherapy phase, respectively. There was no significant correlation between the Trp/Kyn ratio in any phase and the response rate. These results suggest that measurement of the Trp/Kyn ratio is not useful for predicting the rate of response to chemotherapy in patients with breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=84897019486&partnerID=8YFLogxK

M3 - Article

C2 - 24393854

AN - SCOPUS:84897019486

VL - 40

SP - 1578

EP - 1580

JO - Unknown Journal

JF - Unknown Journal

IS - 12

ER -

[Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].

Abstract

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