Indoleamine 2, 3-dioxygenase activity during letrozol therapy for an elderly breast cancer patient

Kenichi Sakurai; Shigeru Fujisaki; Hitomi Kubota; Yukiko Hara; Shuhei Suzuki; Keita Adachi; Ryouichi Tornita; Katsuhisa Enomoto; Tomohiro Hirano; Reina Saga; Makoto Makishima

Indoleamine 2, 3-dioxygenase activity during letrozol therapy for an elderly breast cancer patient

Kenichi Sakurai, Shigeru Fujisaki, Hitomi Kubota, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tornita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

We evaluated the clinical significance of indoleamine 2, 3-dioxygenase (IDO) during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan (TrpVkynurenine (Kyn) ratio. Trp and Kyn levels were measured using high performance liquid chromatography (HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlated with the number of metastatic lymph node lesions during letrozol therapy. These results suggest that measuring the Trp/ Kyn ratio may be useful for evaluating immunological metastatic status during endocrine therapy in elderly patients with locally advanced breast cancer.

Original language	English
Pages (from-to)	892-895
Number of pages	4
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	44
Issue number	10
Publication status	Published - Oct 2017

Keywords

3-dioxygenase (IDO)
Breast cancer
Indoleamine 2
Letrozol therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{60f501f961d24970aa82c17cd1ac5d74,

title = "Indoleamine 2, 3-dioxygenase activity during letrozol therapy for an elderly breast cancer patient",

abstract = "We evaluated the clinical significance of indoleamine 2, 3-dioxygenase (IDO) during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan (TrpVkynurenine (Kyn) ratio. Trp and Kyn levels were measured using high performance liquid chromatography (HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlated with the number of metastatic lymph node lesions during letrozol therapy. These results suggest that measuring the Trp/ Kyn ratio may be useful for evaluating immunological metastatic status during endocrine therapy in elderly patients with locally advanced breast cancer.",

keywords = "3-dioxygenase (IDO), Breast cancer, Indoleamine 2, Letrozol therapy",

author = "Kenichi Sakurai and Shigeru Fujisaki and Hitomi Kubota and Yukiko Hara and Shuhei Suzuki and Keita Adachi and Ryouichi Tornita and Katsuhisa Enomoto and Tomohiro Hirano and Reina Saga and Makoto Makishima",

year = "2017",

month = oct,

language = "English",

volume = "44",

pages = "892--895",

journal = "Japanese Journal of Cancer and Chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

number = "10",

}

TY - JOUR

T1 - Indoleamine 2, 3-dioxygenase activity during letrozol therapy for an elderly breast cancer patient

AU - Sakurai, Kenichi

AU - Fujisaki, Shigeru

AU - Kubota, Hitomi

AU - Hara, Yukiko

AU - Suzuki, Shuhei

AU - Adachi, Keita

AU - Tornita, Ryouichi

AU - Enomoto, Katsuhisa

AU - Hirano, Tomohiro

AU - Saga, Reina

AU - Makishima, Makoto

PY - 2017/10

Y1 - 2017/10

N2 - We evaluated the clinical significance of indoleamine 2, 3-dioxygenase (IDO) during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan (TrpVkynurenine (Kyn) ratio. Trp and Kyn levels were measured using high performance liquid chromatography (HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlated with the number of metastatic lymph node lesions during letrozol therapy. These results suggest that measuring the Trp/ Kyn ratio may be useful for evaluating immunological metastatic status during endocrine therapy in elderly patients with locally advanced breast cancer.

AB - We evaluated the clinical significance of indoleamine 2, 3-dioxygenase (IDO) during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan (TrpVkynurenine (Kyn) ratio. Trp and Kyn levels were measured using high performance liquid chromatography (HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlated with the number of metastatic lymph node lesions during letrozol therapy. These results suggest that measuring the Trp/ Kyn ratio may be useful for evaluating immunological metastatic status during endocrine therapy in elderly patients with locally advanced breast cancer.

KW - 3-dioxygenase (IDO)

KW - Breast cancer

KW - Indoleamine 2

KW - Letrozol therapy

UR - http://www.scopus.com/inward/record.url?scp=85040515035&partnerID=8YFLogxK

M3 - Review article

C2 - 29066687

AN - SCOPUS:85040515035

SN - 0385-0684

VL - 44

SP - 892

EP - 895

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 10

ER -

Indoleamine 2, 3-dioxygenase activity during letrozol therapy for an elderly breast cancer patient

Abstract

Keywords

UN SDGs

Other files and links

Fingerprint

Cite this