Increased subjective distaste and altered insula activity to umami tastant in patients with bulimia nervosa

Rikukage Setsu, Yoshiyuki Hirano, Miki Tokunaga, Toru Takahashi, Noriko Numata, Koji Matsumoto, Yoshitada Masuda, Daisuke Matsuzawa, Masaomi Iyo, Eiji Shimizu, Michiko Nakazato

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The aim of this study was to examine differences in brain neural activation in response to monosodium glutamate (MSG), the representative component of umami, between patients with bulimia nervosa (BN) and healthy women (HW) controls. We analyzed brain activity after ingestion of an MSG solution using functional magnetic resonance imaging (fMRI) in a group of women with BN (n = 18) and a group of HW participants (n = 18). Both groups also provided a subjective assessment of the MSG solution via a numerical rating scale. The BN group subjectively rated the MSG solution lower in pleasantness and liking than the control group, although no difference in subjective intensity was noted. The fMRI results demonstrated greater activation of the right insula in the BN group versus the control group. Compared with the HW controls, the BN patients demonstrated both altered taste perception-related brain activity and more negative hedonic scores in response to MSG stimuli. Different hedonic evaluation, expressed as the relative low pleasing taste of umami tastant and associated with altered insula function, may explain disturbed eating behaviors, including the imbalance in food choices, in BN patients.

Original languageEnglish
Article number172
JournalFrontiers in Psychiatry
Volume8
Issue numberSEP
DOIs
Publication statusPublished - 25 Sept 2017
Externally publishedYes

Keywords

  • Bulimia nervosa
  • Eating disorders
  • Functional magnetic resonance imaging
  • Glutamate
  • Gustation
  • Insula
  • Neuroimaging
  • Umami

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