Impact of body mass index in patients with tricuspid regurgitation after transcatheter edge-to-edge repair

Johanna Vogelhuber, Tetsu Tenaka, Mitsumasa Sudo, Atsushi Sugiura, Can Öztürk, Refik Kavsur, Anika Donner, Georg Nickenig, Sebastian Zimmer, Marcel Weber, Nihal Wilde

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Obesity and underweight represent classical risk factors for outcome in patients treated for cardiovascular disease. This study describes the impact of different body mass index (BMI) categories on 1-year clinical outcome in patients with tricuspid regurgitation (TR) undergoing transcatheter-edge-to-edge repair (TEER). Methods: We analyzed 211 consecutive patients (age 78.3 ± 7.2 years, 55.5% female, median EuroSCORE II 9.6 ± 6.7) with tricuspid regurgitation undergoing TEER from June 2015 until May 2021. Patients were prospectively enrolled in our single center registry and were retrospectively analyzed. Patients were stratified according to body mass index (BMI) into 4 groups: BMI < 20 kg/m2 (underweight), BMI 20.0 to < 25.0 kg/m2 (normal weight), BMI 25.0 to > 30.0 kg/m2 (overweight) and BMI ≥ 30 kg/m2 (obese). Results: Kaplan–Meier survival curves demonstrated inferior survival for underweight and obese patients, but comparable outcomes for normal and overweight patients (global log rank test, p < 0.01). Cardiovascular death was significantly higher in underweight patients compared to the other groups (24.1% vs. 7.0% vs. 6.3% vs. 6.4%; p < 0.01). Over all, there were comparable rates of bleeding, stroke and myocardial infarction. Multivariable Cox regression analysis (adjusted for age, gender, coronary artery disease, chronic obstructive pulmonary disease, tricuspid annular plane systolic excursion, left-ventricular ejection fraction) confirmed underweight (HR 3.88; 95% CI 1.64–7.66; p < 0.01) and obesity (HR 3.24; 95% CI 1.37–9.16; p < 0.01) as independent risk factors for 1-year all-cause mortality. Conclusions: Compared to normal weight and overweight patients, obesity and underweight patients undergoing TEER display significant higher 1-year all-cause mortality. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)156-167
Number of pages12
JournalClinical Research in Cardiology
Issue number1
Publication statusPublished - Jan 2024
Externally publishedYes


  • Body mass index
  • Transcatheter edge-to-edge repair
  • Tricuspid regurgitation
  • Tricuspid valve disease


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