TY - JOUR
T1 - Imaging Analysis Enables Differentiation of the Distribution of Pharmaceutical Ingredients in Tacrolimus Ointments
AU - Fujii, Mika Yoshimura
AU - Yamamoto, Yoshihisa
AU - Koide, Tatsuo
AU - Hamaguchi, Masashi
AU - Onuki, Yoshinori
AU - Suzuki, Naoto
AU - Suzuki, Toyofumi
AU - Fukami, Toshiro
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - We demonstrated the difference in the distribution state of pharmaceutical ingredients between tacrolimus (TCR) original ointment and six kinds of generic medicines. Two-dimensional imaging and depth analysis using attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy and confocal Raman microscopy were used, in addition to the evaluation of pharmaceutical properties, including spreading properties, rheological properties, and amount of solvent. The solvents, such as propylene carbonate and triacetin, in TCR ointments formed liquid droplets and dispersed in hydrocarbon oils. Waxes, white beeswax and beeswax, formed other domains. Confocal Raman microscopy could detect liquid droplet size without coalescence of that on germanium or glass surfaces. The combination of ATR FT-IR and confocal Raman imaging would be a powerful tool to reveal the size and shape of liquid droplets of pharmaceutical ingredients in semisolid formulations.
AB - We demonstrated the difference in the distribution state of pharmaceutical ingredients between tacrolimus (TCR) original ointment and six kinds of generic medicines. Two-dimensional imaging and depth analysis using attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy and confocal Raman microscopy were used, in addition to the evaluation of pharmaceutical properties, including spreading properties, rheological properties, and amount of solvent. The solvents, such as propylene carbonate and triacetin, in TCR ointments formed liquid droplets and dispersed in hydrocarbon oils. Waxes, white beeswax and beeswax, formed other domains. Confocal Raman microscopy could detect liquid droplet size without coalescence of that on germanium or glass surfaces. The combination of ATR FT-IR and confocal Raman imaging would be a powerful tool to reveal the size and shape of liquid droplets of pharmaceutical ingredients in semisolid formulations.
KW - confocal Raman spectroscopy
KW - imaging analysis
KW - rheological property
KW - Tacrolimus ointments
UR - http://www.scopus.com/inward/record.url?scp=85070335963&partnerID=8YFLogxK
U2 - 10.1177/0003702819863441
DO - 10.1177/0003702819863441
M3 - Article
C2 - 31271295
AN - SCOPUS:85070335963
SN - 0003-7028
VL - 73
SP - 1183
EP - 1192
JO - Applied Spectroscopy
JF - Applied Spectroscopy
IS - 10
ER -