Identification of molecular target of diallyl trisulfide in leukemic cells

Shun Suda; Kazunari Watanabe; Yuki Tanaka; Kazuhiro Watanabe; Rie Tanaka; Jun Ogihara; Toyohiko Ariga; Tomomi Hosono-Fukao; Takashi Hosono; Taiichiro Seki

doi:10.1080/09168451.2014.921563

Identification of molecular target of diallyl trisulfide in leukemic cells

Shun Suda, Kazunari Watanabe, Yuki Tanaka, Kazuhiro Watanabe, Rie Tanaka, Jun Ogihara, Toyohiko Ariga, Tomomi Hosono-Fukao, Takashi Hosono, Taiichiro Seki

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27). Hsp27 is suggested to be one of the molecular target of DATS in U937.

Original language	English
Pages (from-to)	1415-1417
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	78
Issue number	8
DOIs	https://doi.org/10.1080/09168451.2014.921563
Publication status	Published - 2014

Keywords

Diagonal gel electrophoresis
Diallyl trisulfide
Garlic
Heat shock protein 27 (HSP27)
U937

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10.1080/09168451.2014.921563

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title = "Identification of molecular target of diallyl trisulfide in leukemic cells",

abstract = "To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27). Hsp27 is suggested to be one of the molecular target of DATS in U937.",

keywords = "Diagonal gel electrophoresis, Diallyl trisulfide, Garlic, Heat shock protein 27 (HSP27), U937",

author = "Shun Suda and Kazunari Watanabe and Yuki Tanaka and Kazuhiro Watanabe and Rie Tanaka and Jun Ogihara and Toyohiko Ariga and Tomomi Hosono-Fukao and Takashi Hosono and Taiichiro Seki",

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language = "English",

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T1 - Identification of molecular target of diallyl trisulfide in leukemic cells

AU - Suda, Shun

AU - Watanabe, Kazunari

AU - Tanaka, Yuki

AU - Watanabe, Kazuhiro

AU - Tanaka, Rie

AU - Ogihara, Jun

AU - Ariga, Toyohiko

AU - Hosono-Fukao, Tomomi

AU - Hosono, Takashi

AU - Seki, Taiichiro

PY - 2014

Y1 - 2014

N2 - To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27). Hsp27 is suggested to be one of the molecular target of DATS in U937.

AB - To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27). Hsp27 is suggested to be one of the molecular target of DATS in U937.

KW - Diagonal gel electrophoresis

KW - Diallyl trisulfide

KW - Garlic

KW - Heat shock protein 27 (HSP27)

KW - U937

UR - https://www.scopus.com/pages/publications/84928088937

U2 - 10.1080/09168451.2014.921563

DO - 10.1080/09168451.2014.921563

M3 - Article

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AN - SCOPUS:84928088937

SN - 0916-8451

VL - 78

SP - 1415

EP - 1417

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 8

ER -

Identification of molecular target of diallyl trisulfide in leukemic cells

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Keywords

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