TY - JOUR
T1 - Helicobacter pylori infection is positively associated with gallstones
T2 - A large-scale cross-sectional study in Japan
AU - Takahashi, Yu
AU - Yamamichi, Nobutake
AU - Shimamoto, Takeshi
AU - Mochizuki, Satoshi
AU - Fujishiro, Mitsuhiro
AU - Takeuchi, Chihiro
AU - Sakaguchi, Yoshiki
AU - Niimi, Keiko
AU - Ono, Satoshi
AU - Kodashima, Shinya
AU - Mitsushima, Toru
AU - Koike, Kazuhiko
PY - 2014/5
Y1 - 2014/5
N2 - Background: Our aim is to elucidate causative factors for gallstones, especially focusing on Helicobacter pylori (HP) infection. Methods: We analyzed 15,551 Japanese adults who had no history of gastrectomy, cholecystectomy, HP eradication, and didn't use proton pump inhibitors, anti-diabetic drugs, or anti-cholesterol drugs. 1,057 subjects who previously had HP eradication were analyzed separately. Results: Gallstones were detected in 409 of 8,625 men (4.74 %) and 285 of 6,926 women (4.11 %) by ultrasonography. Among the 25 factors univariately analyzed, age, HP infection, alcohol intake, weight, body mass index (BMI), and 14 blood test values (AST, ALT, ALP, γ-GTP, T-Chol, HDL-Chol, LDL-Chol, TG, TP, Hb, HbA1c, pepsinogen I, pepsinogen II, and pepsinogen I/II ratio) displayed significant association with gallstones (p < 0.05), whereas gender, smoking, height, and three blood test values (Alb, T-Bil, MCV) did not. Multivariate analysis showed that age, gender, alcohol intake, BMI, γ-GTP, LDL-Chol, TP, and HP infection had significant association (p < 0.05). Successive multiple logistic regression analysis calculating odds ratio (OR) and standardized coefficients (β) showed that age (OR/β = 1.57/0.450), BMI (OR/β = 1.30/0.264), HP infection (OR/β = 1.51/0.206), lower alcohol intake (OR/β = 1.33/0.144), γ-GTP (OR/β = 1.15/0.139), and pepsinogen I/II ratio (OR/β = 1.08/0.038) have significant positive association with gallstones, whereas gender does not. The gallstone prevalence among HP-negative, HP-eradicated, and HP-positive subjects was 3.81, 4.73 and 6.08 %, respectively. The matched analysis controlling age, BMI, γ-GTP, alcohol intake, pepsinogen I/II ratio and gender also demonstrated that gallstone prevalence among HP-eradicated subjects was significantly lower compared with HP-positive subjects (p < 0.05). Conclusions: HP infection is positively associated with gallstones. HP eradication may lead to prevention of gallstones.
AB - Background: Our aim is to elucidate causative factors for gallstones, especially focusing on Helicobacter pylori (HP) infection. Methods: We analyzed 15,551 Japanese adults who had no history of gastrectomy, cholecystectomy, HP eradication, and didn't use proton pump inhibitors, anti-diabetic drugs, or anti-cholesterol drugs. 1,057 subjects who previously had HP eradication were analyzed separately. Results: Gallstones were detected in 409 of 8,625 men (4.74 %) and 285 of 6,926 women (4.11 %) by ultrasonography. Among the 25 factors univariately analyzed, age, HP infection, alcohol intake, weight, body mass index (BMI), and 14 blood test values (AST, ALT, ALP, γ-GTP, T-Chol, HDL-Chol, LDL-Chol, TG, TP, Hb, HbA1c, pepsinogen I, pepsinogen II, and pepsinogen I/II ratio) displayed significant association with gallstones (p < 0.05), whereas gender, smoking, height, and three blood test values (Alb, T-Bil, MCV) did not. Multivariate analysis showed that age, gender, alcohol intake, BMI, γ-GTP, LDL-Chol, TP, and HP infection had significant association (p < 0.05). Successive multiple logistic regression analysis calculating odds ratio (OR) and standardized coefficients (β) showed that age (OR/β = 1.57/0.450), BMI (OR/β = 1.30/0.264), HP infection (OR/β = 1.51/0.206), lower alcohol intake (OR/β = 1.33/0.144), γ-GTP (OR/β = 1.15/0.139), and pepsinogen I/II ratio (OR/β = 1.08/0.038) have significant positive association with gallstones, whereas gender does not. The gallstone prevalence among HP-negative, HP-eradicated, and HP-positive subjects was 3.81, 4.73 and 6.08 %, respectively. The matched analysis controlling age, BMI, γ-GTP, alcohol intake, pepsinogen I/II ratio and gender also demonstrated that gallstone prevalence among HP-eradicated subjects was significantly lower compared with HP-positive subjects (p < 0.05). Conclusions: HP infection is positively associated with gallstones. HP eradication may lead to prevention of gallstones.
KW - Cross-sectional study
KW - Gallstone
KW - Helicobacter pylori
UR - http://www.scopus.com/inward/record.url?scp=84901398932&partnerID=8YFLogxK
U2 - 10.1007/s00535-013-0832-z
DO - 10.1007/s00535-013-0832-z
M3 - Article
C2 - 23736795
AN - SCOPUS:84901398932
SN - 0944-1174
VL - 49
SP - 882
EP - 889
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
IS - 5
ER -
