Follow-up results of HCV GT2 patients after sofosbuvir/ribavirin therapy: Careful attention to occurrence of HCC

Tomohiro Kaneko, Tatsuo Kanda, Kazushige Nirei, Naoki Matsumoto, Motomi Yamazaki, Toshikatsu Shibata, Akinori Tamura, Masahiro Ogawa, Noriko Nakajima, Shunichi Matsuoka, Kazumichi Kuroda, Tomoe Komoriya, Tatsuo Yamamoto, Tadatoshi Takayama, Mitsuhiko Moriyama

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: We examined treatment the efficacy and data on long-term outcomes in real-world Japanese patients infected with hepatitis C virus (HCV) genotype 2 treated with 12-week sofosbuvir/ribavirin combination therapy. Patients and Methods: In a total of 86 patients who were treated with sofosbuvir/ribavirin, sustained virological response (SVR) rates and long-term-outcomes were retrospectively analyzed. Results: The adherence to this combination therapy was 98.8%. The rates of SVR at week 24 (SVR24) achieved with this treatment according to the ‘intention-to-treat’and ‘per-protocol’ analyses were 89.5% and 96.2%, respectively. Two patients who experienced relapse did not have any previously reported resistance-associated substitutions in the HCV non-structural protein 5B (NS5B) polymerase region. We did not observe any patients who experienced late relapse but did observe that 50% and 1.3% of patients with and without a previous history of hepatocellular carcinoma (HCC), respectively, developed HCC after achieving SVR24 (with a mean follow-up period of 2.7±0.8 years). Conclusion: Patients with SVR should be carefully followed-up to screen for the occurrence of HCC, although it is infrequent.

Original languageEnglish
Pages (from-to)3855-3862
Number of pages8
JournalAnticancer Research
Volume39
Issue number7
DOIs
Publication statusPublished - 2019

Keywords

  • HCC
  • HCV
  • Late relapse
  • RAS
  • SVR

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