Epidemiology, Pathophysiology, Diagnosis, and Therapy of Heart Failure With Preserved Ejection Fraction in Japan

MASARU OBOKATA, HIDEMI SORIMACHI, TOMONARI HARADA, KAZUKI KAGAMI, Y. U.K.I. SAITO, HIDEKI ISHII

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Heart failure (HF) with preserved ejection fraction (HFpEF) is a global health care problem, with diagnostic difficulty, limited treatment options and high morbidity and mortality rates. The prevalence of HFpEF is increasing because of the aging population and the increasing burden of cardiac and metabolic comorbidities, such as systemic hypertension, diabetes, chronic kidney disease, and obesity. The knowledge base is derived primarily from the United States and Europe, and data from Asian countries, including Japan, remain limited. Given that phenotypic differences may exist between Japanese and Western patients with HFpEF, careful characterization may hold promise to deliver new therapy specific to the Japanese population. In this review, we summarize the current knowledge regarding the epidemiology, pathophysiology and diagnosis of and the potential therapies for HFpEF in Japan.

Original languageEnglish
Pages (from-to)375-388
Number of pages14
JournalJournal of Cardiac Failure
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2023

Keywords

  • Asia
  • Japan
  • ethnic differences
  • heart failure

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