Efficacy of a microballoon catheter in transarterial chemoembolization of hepatocellular carcinoma using miriplatin, a lipophilic anticancer drug: Short-term results

Masahiro Ogawa, Kentaro Takayasu, Midori Hirayama, Takao Miura, Katsuhiko Shiozawa, Masahisa Abe, Naoki Matsumoto, Hiroshi Nakagawara, Shu Ohshiro, Toshiki Yamamoto, Naohide Tanaka, Mitsuhiko Moriyama, Haruomi Mutou, Yoshinobu Yamamoto, Toshiyuki Irie

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32 Citations (Scopus)

Abstract

Aim: The goal of the study was to evaluate the efficacy and safety of balloon-occluded transarterial chemoembolization (B-TACE) of hepatocellular carcinoma (HCC) using miriplatin (a lipophilic anticancer drug) and gelatin particles. Methods: B-TACE was performed for 62 HCC nodules in 33 patients who could not be treated by surgical resection or radiofrequency ablation. All 33 patients had a history of transarterial chemoembolization (TACE) treatment prior to B-TACE. As a historical comparison, we investigated 40 nodules in 28 patients treated by TACE using a conventional microcatheter (C-TACE), miriplatin and gelatin particles. The therapeutic effect per tumor was compared between the groups based on the Response Evaluation Criteria in Cancer Study Group of Japan (RECICL) and side-effects were compared based on the Common Terminology Criteria for Adverse Events (ver.4.0). Results: The therapeutic efficacy after 4-12weeks was evaluated in 59 nodules in the B-TACE group and in 37 nodules in the C-TACE group. Of these nodules, TE4 occurred in 29 (49.2%) in the B-TACE group and in 10 (27%) in the C-TACE group. Local efficacy was significantly higher in nodules treated by B-TACE than by C-TACE. The side-effects on hepatic function were similar in the two groups. Conclusion: Our results suggest that B-TACE with miriplatin is a useful treatment for hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)E60-E69
JournalHepatology Research
Volume46
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • Balloon occlusion
  • Balloon-occluded transarterial chemoembolization
  • Conventional microcatheter transcatheter arterial chemoembolization
  • Embolization
  • Hepatocellular carcinoma
  • Miriplatin

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