Diffuse alveolar hemorrhage associated with makyo-kanseki-to administration

Yuko Iida; Yuki Takano; Yusaku Ishiwatari; Akiko Yoshida; Tetsuo Shimizu; Reiko Ito; Tomohiro Hattori; Noriaki Takahashi; Shu Hashimoto

doi:10.2169/internalmedicine.55.6986

Diffuse alveolar hemorrhage associated with makyo-kanseki-to administration

Yuko Iida, Yuki Takano, Yusaku Ishiwatari, Akiko Yoshida, Tetsuo Shimizu, Reiko Ito, Tomohiro Hattori, Noriaki Takahashi, Shu Hashimoto

School of Medicine

Nihon University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.

Original language	English
Pages (from-to)	3321-3323
Number of pages	3
Journal	Internal Medicine
Volume	55
Issue number	22
DOIs	https://doi.org/10.2169/internalmedicine.55.6986
Publication status	Published - 2016

Keywords

Chinese herbal drugs
Diffuse alveolar hemorrhage
Drug-induced interstitial pneumonia

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10.2169/internalmedicine.55.6986

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title = "Diffuse alveolar hemorrhage associated with makyo-kanseki-to administration",

abstract = "We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.",

keywords = "Chinese herbal drugs, Diffuse alveolar hemorrhage, Drug-induced interstitial pneumonia",

author = "Yuko Iida and Yuki Takano and Yusaku Ishiwatari and Akiko Yoshida and Tetsuo Shimizu and Reiko Ito and Tomohiro Hattori and Noriaki Takahashi and Shu Hashimoto",

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year = "2016",

doi = "10.2169/internalmedicine.55.6986",

language = "English",

volume = "55",

pages = "3321--3323",

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TY - JOUR

T1 - Diffuse alveolar hemorrhage associated with makyo-kanseki-to administration

AU - Iida, Yuko

AU - Takano, Yuki

AU - Ishiwatari, Yusaku

AU - Yoshida, Akiko

AU - Shimizu, Tetsuo

AU - Ito, Reiko

AU - Hattori, Tomohiro

AU - Takahashi, Noriaki

AU - Hashimoto, Shu

PY - 2016

Y1 - 2016

N2 - We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.

AB - We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.

KW - Chinese herbal drugs

KW - Diffuse alveolar hemorrhage

KW - Drug-induced interstitial pneumonia

UR - https://www.scopus.com/pages/publications/84995701499

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DO - 10.2169/internalmedicine.55.6986

M3 - Article

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AN - SCOPUS:84995701499

SN - 0918-2918

VL - 55

SP - 3321

EP - 3323

JO - Internal Medicine

JF - Internal Medicine

IS - 22

ER -

Diffuse alveolar hemorrhage associated with makyo-kanseki-to administration

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Keywords

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