Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus

Suguru Mizuno; Hiroyuki Isayama; Yousuke Nakai; Kazunaga Ishigaki; Kei Saito; Tatsuya Sato; Tsuyoshi Takeda; Ryunosuke Hakuta; Tomotaka Saito; Naminatsu Takahara; Hirofumi Kogure; Hideaki Ijichi; Keisuke Tateishi; Minoru Tada; Nahoko Shikata; Tomoyuki Tagami; Shinya Kikuchi; Hiroshi Yamamoto; Minoru Yamakado; Kazuhiko Koike

doi:10.1016/j.pan.2019.07.002

Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus

Suguru Mizuno, Hiroyuki Isayama, Yousuke Nakai, Kazunaga Ishigaki, Kei Saito, Tatsuya Sato, Tsuyoshi Takeda, Ryunosuke Hakuta, Tomotaka Saito, Naminatsu Takahara, Hirofumi Kogure, Hideaki Ijichi, Keisuke Tateishi, Minoru Tada, Nahoko Shikata, Tomoyuki Tagami, Shinya Kikuchi, Hiroshi Yamamoto, Minoru Yamakado, Kazuhiko Koike

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objectives: A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM. Methods: We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status. Results: A total of 180 case–control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P = 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P = 0.95). Conclusions: This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM.

Original language	English
Pages (from-to)	695-698
Number of pages	4
Journal	Pancreatology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.pan.2019.07.002
Publication status	Published - Jul 2019
Externally published	Yes

Keywords

Amino acid
Biomarker
Diabetes mellitus
Metabolomics
Pancreatic cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pan.2019.07.002

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Mizuno, S., Isayama, H., Nakai, Y., Ishigaki, K., Saito, K., Sato, T., Takeda, T., Hakuta, R., Saito, T., Takahara, N., Kogure, H., Ijichi, H., Tateishi, K., Tada, M., Shikata, N., Tagami, T., Kikuchi, S., Yamamoto, H., Yamakado, M., & Koike, K. (2019). Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus. Pancreatology, 19(5), 695-698. https://doi.org/10.1016/j.pan.2019.07.002

@article{78130512c2f44ea78ce25ded5e219397,

title = "Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus",

abstract = "Objectives: A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM. Methods: We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status. Results: A total of 180 case–control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P = 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P = 0.95). Conclusions: This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM.",

keywords = "Amino acid, Biomarker, Diabetes mellitus, Metabolomics, Pancreatic cancer",

author = "Suguru Mizuno and Hiroyuki Isayama and Yousuke Nakai and Kazunaga Ishigaki and Kei Saito and Tatsuya Sato and Tsuyoshi Takeda and Ryunosuke Hakuta and Tomotaka Saito and Naminatsu Takahara and Hirofumi Kogure and Hideaki Ijichi and Keisuke Tateishi and Minoru Tada and Nahoko Shikata and Tomoyuki Tagami and Shinya Kikuchi and Hiroshi Yamamoto and Minoru Yamakado and Kazuhiko Koike",

note = "Publisher Copyright: {\textcopyright} 2019 IAP and EPC",

year = "2019",

month = jul,

doi = "10.1016/j.pan.2019.07.002",

language = "English",

volume = "19",

pages = "695--698",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "Elsevier B.V.",

number = "5",

}

Mizuno, S, Isayama, H, Nakai, Y, Ishigaki, K, Saito, K, Sato, T, Takeda, T, Hakuta, R, Saito, T, Takahara, N, Kogure, H, Ijichi, H, Tateishi, K, Tada, M, Shikata, N, Tagami, T, Kikuchi, S, Yamamoto, H, Yamakado, M & Koike, K 2019, 'Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus', Pancreatology, vol. 19, no. 5, pp. 695-698. https://doi.org/10.1016/j.pan.2019.07.002

TY - JOUR

T1 - Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus

AU - Mizuno, Suguru

AU - Isayama, Hiroyuki

AU - Nakai, Yousuke

AU - Ishigaki, Kazunaga

AU - Saito, Kei

AU - Sato, Tatsuya

AU - Takeda, Tsuyoshi

AU - Hakuta, Ryunosuke

AU - Saito, Tomotaka

AU - Takahara, Naminatsu

AU - Kogure, Hirofumi

AU - Ijichi, Hideaki

AU - Tateishi, Keisuke

AU - Tada, Minoru

AU - Shikata, Nahoko

AU - Tagami, Tomoyuki

AU - Kikuchi, Shinya

AU - Yamamoto, Hiroshi

AU - Yamakado, Minoru

AU - Koike, Kazuhiko

PY - 2019/7

Y1 - 2019/7

N2 - Objectives: A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM. Methods: We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status. Results: A total of 180 case–control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P = 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P = 0.95). Conclusions: This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM.

AB - Objectives: A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM. Methods: We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status. Results: A total of 180 case–control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P = 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P = 0.95). Conclusions: This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM.

KW - Amino acid

KW - Biomarker

KW - Diabetes mellitus

KW - Metabolomics

KW - Pancreatic cancer

UR - http://www.scopus.com/inward/record.url?scp=85068851986&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2019.07.002

DO - 10.1016/j.pan.2019.07.002

M3 - Article

C2 - 31320196

AN - SCOPUS:85068851986

SN - 1424-3903

VL - 19

SP - 695

EP - 698

JO - Pancreatology

JF - Pancreatology

IS - 5

ER -

Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus

Abstract

Keywords

UN SDGs

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