Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis

Shinta Suzuki, Akira Aoki, Sayaka Katagiri, Shogo Maekawa, Kenichiro Ejiri, Sophannary Kong, Mizuki Nagata, Yoko Yamaguchi, Mitsuhiro Ohshima, Yuichi Izumi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The aim of this study is to analyze the relationship between Hepatocyte Growth Factor (HGF levels in oral rinses using water and clinical parameters of periodontitis; and furthermore, to evaluate the potential of a prototype HGF immunochromatographic paper test strip (HGF-TS for screening of periodontitis, in comparison with a commer-cially-available occult blood (hemoglobin test strip (Hb-TS. Clinical periodontal parameters were recorded, and oral rinses were collected, from 125 subjects. Then, the presence of HGF, and hemoglobin (Hb, in each sample was detected using a prototype HGF-TS and an Hb-TS. In addition, the concentrations of HGF and Hb were also determined in each sample is necessary HGF concentrations in oral rinses showed significant correlations with clinical parameters of periodontitis. The positive rate and read value on HGF-TS showed significantly high values in cases of severe periodontitis compared to healthy subjects. Hb-TS showed generally higher positive rates than HGF-TS; however, it showed false positive results in healthy subjects. The concentration of HGF in oral rinses showed close association with the severity of periodontitis, suggesting that the prototype HGF-TS has potential for use in the diagnosis of periodontitis, although further refinement of the test strip is required to increase the sensitivity.

Original languageEnglish
Article numberjosnusd.18-0226
Pages (from-to)250-255
Number of pages6
JournalJournal of Oral Science
Issue number3
Publication statusPublished - Jul 2020


  • Hepatocyte growth factor
  • Immunochromatgraphic paper
  • Mass-screening test
  • Occult blood test
  • Periodontitis


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