Cutaneous papilloma and multicentric squamous cell carcinoma in four-toed hedgehogs (Atelerix albiventris)

Naka Okumura, Iori Koizumi, Yuki Iwata, Shion Yoneya, Ryota Koba, Hirotaka Kondo, Hisashi Shibuya

Research output: Contribution to journalComment/debate

2 Citations (Scopus)


Skin lesions possibly caused by Papillomavirus infections in two four-toed hedgehogs are described. In case 1, there was a papillary mass on the right hind limb. Histologically, the mass was consistent with a viral papilloma. In the other case, multifocal papillary masses with erosions and ulcers were found throughout the body, mainly on the extremities. Histology showed continuative lesions composed of acanthosis, Bowenoid in situ carcinoma, and squamous cell carcinoma, with abrupt transitions between the lesions. In both cases, keratinocytes in the granular layer infrequently had features of koilocytes and intranuclear inclusion bodies, and immunohistochemical staining was positive for anti-human papillomavirus antibody. To the best of the authors’ knowledge, this is the first pathological documentation of possibly papillomavirus-associated skin lesions in four-toed hedgehogs.

Original languageEnglish
Pages (from-to)1726-1729
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number11
Publication statusPublished - 2021


  • Four-toed hedgehog
  • Histopathology
  • Neoplasm
  • Papillomavirus


Dive into the research topics of 'Cutaneous papilloma and multicentric squamous cell carcinoma in four-toed hedgehogs (Atelerix albiventris)'. Together they form a unique fingerprint.

Cite this