Continual gram-negative bacterial challenge accelerates stroke onset in stroke-prone spontaneously hypertensive rats

Takayuki Kawato; Hideki Tanaka; Masaki Tabuchi; Kana Ooshima; Kumiko Nakai; Yoshihisa Yamashita; Masao Maeno

doi:10.3109/10641963.2012.689042

Continual gram-negative bacterial challenge accelerates stroke onset in stroke-prone spontaneously hypertensive rats

Takayuki Kawato, Hideki Tanaka, Masaki Tabuchi, Kana Ooshima, Kumiko Nakai, Yoshihisa Yamashita, Masao Maeno

School of Dentistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in LPS-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, thiobarbituric acid reactive substance, and 8-hydroxydeoxyguanosine increased in LPS-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from LPSs.

Original language	English
Pages (from-to)	28-34
Number of pages	7
Journal	Clinical and Experimental Hypertension
Volume	35
Issue number	1
DOIs	https://doi.org/10.3109/10641963.2012.689042
Publication status	Published - 2013

Keywords

Chronic infections
Gram-negative bacteria
Lipopolysaccharide
Stroke
Stroke-prone spontaneously hypertensive rats (SHRSP)

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10.3109/10641963.2012.689042

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abstract = "This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in LPS-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, thiobarbituric acid reactive substance, and 8-hydroxydeoxyguanosine increased in LPS-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from LPSs.",

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AU - Kawato, Takayuki

AU - Tanaka, Hideki

AU - Tabuchi, Masaki

AU - Ooshima, Kana

AU - Nakai, Kumiko

AU - Yamashita, Yoshihisa

AU - Maeno, Masao

PY - 2013

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KW - Lipopolysaccharide

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Continual gram-negative bacterial challenge accelerates stroke onset in stroke-prone spontaneously hypertensive rats

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Keywords

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