TY - JOUR
T1 - Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children
AU - Okahashi, Aya
AU - Okada, Tomoo
AU - Saito, Emiko
AU - Miyashita, Michio
AU - Kuromori, Yuki
AU - Iwata, Fujihiko
AU - Hara, Mitsuhiko
AU - Mugishima, Hideo
AU - Kitamura, Yohei
AU - Shimizu, Takashi
PY - 2009/3
Y1 - 2009/3
N2 - Background: Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults. Methods: Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured. Results: Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors. Conclusions: Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.
AB - Background: Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults. Methods: Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured. Results: Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors. Conclusions: Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.
KW - Abdominal obesity
KW - Childhood obesity
KW - Hexacosanoic acid(C26:0)
KW - Very long-chain fatty acid
UR - http://www.scopus.com/inward/record.url?scp=58549096914&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2008.12.013
DO - 10.1016/j.cca.2008.12.013
M3 - Article
C2 - 19135040
AN - SCOPUS:58549096914
SN - 0009-8981
VL - 401
SP - 141
EP - 143
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1-2
ER -
