COMMD5 inhibits malignant behavior of renal cancer cells

Jin Ikeda, Hiroyuki Matsuda, Maiko Ogasawara, Yukimoto Ishii, Kenya Yamaguchi, Satoru Takahashi, Noboru Fukuda, Yoshikazu Masuhiro, Morito Endo, Masayoshi Soma, Pavel Hamet, Johanne Tremblay

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background/Aim: Copper metabolism MURR1 domain-containing 5 (COMMD5) is mainly expressed in renal tubules (RTs), where it facilitates re-differentiation of injured RTs. We reported that COMMD5 regulates the expression of epidermal growth factor receptor by participating in its endocytic membrane trafficking, thus inhibiting tumor growth. Here we aimed to determine the role of COMMD5 in malignant phenotypes of renal cell carcinoma (RCC). Materials and Methods: The associations between COMMD5 levels in RTs adjacent to RCC tumors in patients and their clinicopathologic characteristics were evaluated, and the effects of COMMD5 on cancer stemness in RCC cells were investigated. Results: Low COMMD5 levels in RTs correlated with high tumorigenesis and poor patient outcomes. COMMD5 overexpression in RCC cells reduced the proportion of cancer stem cell-like cells and their malignant phenotypes, including proliferation, invasion and sphere formation. Secreted COMMD5 from RT cells also reduced malignant phenotypes. Conclusion: COMMD5 might suppress malignant phenotypes of RCC, thus inhibiting tumor development and improving patient prognosis.

Original languageEnglish
Pages (from-to)2805-2815
Number of pages11
JournalAnticancer Research
Issue number6
Publication statusPublished - Jun 2021


  • COMMD5
  • Cancer stem cell
  • Metastasis and recurrence
  • Renal cell carcinoma
  • Renal tubules


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