Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC

Kazuo Sakamoto; Tetsuya Matoba; Michikazu Nakai; Yoshio Tahara; Takahiro Nakashima; Hayato Hosoda; Yoshihiro Miyamoto; Kunihiro Nishimura; Yoko Sumita; Tsukasa Yagi; Kenzo Ichimura; Naohiro Yonemoto; Eizo Tachibana; Ken Nagao; Takanori Ikeda; Naoki Sato; Hiroyuki Tsutsui

doi:10.1007/s00380-022-02158-0

Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC

Kazuo Sakamoto, Tetsuya Matoba, Michikazu Nakai, Yoshio Tahara, Takahiro Nakashima, Hayato Hosoda, Yoshihiro Miyamoto, Kunihiro Nishimura, Yoko Sumita, Tsukasa Yagi, Kenzo Ichimura, Naohiro Yonemoto, Eizo Tachibana, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui

Research output: Contribution to journal › Article › peer-review

Abstract

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used for critically ill patients all over the world; however, comprehensive survey regarding the relationship between VA-ECMO duration and prognosis is limited. We conducted a survey of VA-ECMO patients in the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC), which was a health insurance claim database study among cardiovascular centers associated with the Japan Circulation Society, between April 2012 and March 2016. Out of 13,542 VA-ECMO patients, we analyzed 5766 cardiovascular patients treated with VA-ECMO. 68% patients used VA-ECMO only for 1 day and 93% had VA-ECMO terminated within 1 week. In multivariate analysis, the hazard ratio of 1-day support was significantly high at 1.72 (95% confidence intervals; 95% CI 1.53–1.95) (p < 0.001), while that of 2-day [0.60 (95% CI 0.49–0.73)], 3-day [0.75 (95% CI 0.60–0.94)], 4-day [0.43 (95% CI 0.31–0.60)] and 5-day support [0.62 (95% CI 0.44–0.86)] was significantly low. Comprehensive database analysis of JROAD-DPC revealed that cardiovascular patients who were supported with VA-ECMO for 2–5 days showed lower mortality. The optimal VA-ECMO support window should be investigated in further studies.

Original language	English
Pages (from-to)	228-235
Number of pages	8
Journal	Heart and Vessels
Volume	38
Issue number	2
DOIs	https://doi.org/10.1007/s00380-022-02158-0
Publication status	Published - Feb 2023
Externally published	Yes

Keywords

Cardiovascular diseases
Duration
Extracorporeal membrane oxygenation
Multicenter study
Shock

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00380-022-02158-0

Cite this

Sakamoto, K., Matoba, T., Nakai, M., Tahara, Y., Nakashima, T., Hosoda, H., Miyamoto, Y., Nishimura, K., Sumita, Y., Yagi, T., Ichimura, K., Yonemoto, N., Tachibana, E., Nagao, K., Ikeda, T., Sato, N., & Tsutsui, H. (2023). Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC. Heart and Vessels, 38(2), 228-235. https://doi.org/10.1007/s00380-022-02158-0

@article{307ef59413c14d7e910c1e20293581bc,

title = "Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC",

abstract = "Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used for critically ill patients all over the world; however, comprehensive survey regarding the relationship between VA-ECMO duration and prognosis is limited. We conducted a survey of VA-ECMO patients in the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC), which was a health insurance claim database study among cardiovascular centers associated with the Japan Circulation Society, between April 2012 and March 2016. Out of 13,542 VA-ECMO patients, we analyzed 5766 cardiovascular patients treated with VA-ECMO. 68% patients used VA-ECMO only for 1 day and 93% had VA-ECMO terminated within 1 week. In multivariate analysis, the hazard ratio of 1-day support was significantly high at 1.72 (95% confidence intervals; 95% CI 1.53–1.95) (p < 0.001), while that of 2-day [0.60 (95% CI 0.49–0.73)], 3-day [0.75 (95% CI 0.60–0.94)], 4-day [0.43 (95% CI 0.31–0.60)] and 5-day support [0.62 (95% CI 0.44–0.86)] was significantly low. Comprehensive database analysis of JROAD-DPC revealed that cardiovascular patients who were supported with VA-ECMO for 2–5 days showed lower mortality. The optimal VA-ECMO support window should be investigated in further studies.",

keywords = "Cardiovascular diseases, Duration, Extracorporeal membrane oxygenation, Multicenter study, Shock",

author = "Kazuo Sakamoto and Tetsuya Matoba and Michikazu Nakai and Yoshio Tahara and Takahiro Nakashima and Hayato Hosoda and Yoshihiro Miyamoto and Kunihiro Nishimura and Yoko Sumita and Tsukasa Yagi and Kenzo Ichimura and Naohiro Yonemoto and Eizo Tachibana and Ken Nagao and Takanori Ikeda and Naoki Sato and Hiroyuki Tsutsui",

note = "Publisher Copyright: {\textcopyright} 2022, Springer Japan KK, part of Springer Nature.",

year = "2023",

month = feb,

doi = "10.1007/s00380-022-02158-0",

language = "English",

volume = "38",

pages = "228--235",

journal = "Heart and Vessels",

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Sakamoto, K, Matoba, T, Nakai, M, Tahara, Y, Nakashima, T, Hosoda, H, Miyamoto, Y, Nishimura, K, Sumita, Y, Yagi, T, Ichimura, K, Yonemoto, N, Tachibana, E, Nagao, K, Ikeda, T, Sato, N & Tsutsui, H 2023, 'Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC', Heart and Vessels, vol. 38, no. 2, pp. 228-235. https://doi.org/10.1007/s00380-022-02158-0

TY - JOUR

T1 - Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation

T2 - analysis from JROAD-DPC

AU - Sakamoto, Kazuo

AU - Matoba, Tetsuya

AU - Nakai, Michikazu

AU - Tahara, Yoshio

AU - Nakashima, Takahiro

AU - Hosoda, Hayato

AU - Miyamoto, Yoshihiro

AU - Nishimura, Kunihiro

AU - Sumita, Yoko

AU - Yagi, Tsukasa

AU - Ichimura, Kenzo

AU - Yonemoto, Naohiro

AU - Tachibana, Eizo

AU - Nagao, Ken

AU - Ikeda, Takanori

AU - Sato, Naoki

AU - Tsutsui, Hiroyuki

PY - 2023/2

Y1 - 2023/2

N2 - Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used for critically ill patients all over the world; however, comprehensive survey regarding the relationship between VA-ECMO duration and prognosis is limited. We conducted a survey of VA-ECMO patients in the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC), which was a health insurance claim database study among cardiovascular centers associated with the Japan Circulation Society, between April 2012 and March 2016. Out of 13,542 VA-ECMO patients, we analyzed 5766 cardiovascular patients treated with VA-ECMO. 68% patients used VA-ECMO only for 1 day and 93% had VA-ECMO terminated within 1 week. In multivariate analysis, the hazard ratio of 1-day support was significantly high at 1.72 (95% confidence intervals; 95% CI 1.53–1.95) (p < 0.001), while that of 2-day [0.60 (95% CI 0.49–0.73)], 3-day [0.75 (95% CI 0.60–0.94)], 4-day [0.43 (95% CI 0.31–0.60)] and 5-day support [0.62 (95% CI 0.44–0.86)] was significantly low. Comprehensive database analysis of JROAD-DPC revealed that cardiovascular patients who were supported with VA-ECMO for 2–5 days showed lower mortality. The optimal VA-ECMO support window should be investigated in further studies.

AB - Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used for critically ill patients all over the world; however, comprehensive survey regarding the relationship between VA-ECMO duration and prognosis is limited. We conducted a survey of VA-ECMO patients in the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC), which was a health insurance claim database study among cardiovascular centers associated with the Japan Circulation Society, between April 2012 and March 2016. Out of 13,542 VA-ECMO patients, we analyzed 5766 cardiovascular patients treated with VA-ECMO. 68% patients used VA-ECMO only for 1 day and 93% had VA-ECMO terminated within 1 week. In multivariate analysis, the hazard ratio of 1-day support was significantly high at 1.72 (95% confidence intervals; 95% CI 1.53–1.95) (p < 0.001), while that of 2-day [0.60 (95% CI 0.49–0.73)], 3-day [0.75 (95% CI 0.60–0.94)], 4-day [0.43 (95% CI 0.31–0.60)] and 5-day support [0.62 (95% CI 0.44–0.86)] was significantly low. Comprehensive database analysis of JROAD-DPC revealed that cardiovascular patients who were supported with VA-ECMO for 2–5 days showed lower mortality. The optimal VA-ECMO support window should be investigated in further studies.

KW - Cardiovascular diseases

KW - Duration

KW - Extracorporeal membrane oxygenation

KW - Multicenter study

KW - Shock

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U2 - 10.1007/s00380-022-02158-0

DO - 10.1007/s00380-022-02158-0

M3 - Article

C2 - 36173448

AN - SCOPUS:85139122784

SN - 0910-8327

VL - 38

SP - 228

EP - 235

JO - Heart and Vessels

JF - Heart and Vessels

IS - 2

ER -

Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC

Abstract

Keywords

UN SDGs

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