Characteristics and outcomes of patients undergoing transcatheter mitral valve replacement with the Tendyne system

Nihal Wilde, Tetsu Tanaka, Vivian Vij, Atsushi Sugiura, Mitsumasa Sudo, Eva Eicheler, Miriam Silaschi, Johanna Vogelhuber, Farhad Bakhtiary, Georg Nickenig, Marcel Weber, Sebastian Zimmer

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Transcatheter mitral valve replacement (TMVR) has emerged as alternative to transcatheter edge-to-edge repair (TEER) for treatment of mitral regurgitation (MR); however, the role of TMVR with the Tendyne system among established treatments of MR is not well defined. We assessed characteristics and outcomes of patients treated with the Tendyne system in the current clinical practice. Methods: We reviewed patients who underwent cardiac computed tomography and were judged eligible for the Tendyne system. Results: A total of 63 patients were eligible for TMVR with the Tendyne system. Of these, 17 patients underwent TMVR, and 46 were treated by TEER. Patients treated with the Tendyne system were more likely to have a high transmitral pressure gradient and unsuitable mitral valve morphology for TEER than those treated with TEER. TMVR with the Tendyne system reduced the severity of MR to less than 1 + in 94.1% of the patients at discharge and achieved a greater reduction in left ventricular (LV) end-diastolic volume at the 30-day follow-up compared with TEER. In contrast, patients treated with the Tendyne system had a higher 30-day mortality than those treated with TEER, while the mortality between 30 days and one year was comparable between Tendyne and TEER. Conclusions: Among patients eligible for the Tendyne system, approximately a quarter of the patients underwent TMVR with the Tendyne system, which led substantial reduction of MR and LV reverse remodeling than TEER. In contrast, the 30-day mortality rate was higher after TMVR with the Tendyne compared to TEER.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalClinical Research in Cardiology
Issue number1
Publication statusPublished - Jan 2024
Externally publishedYes


  • Mitral regurgitation
  • Mitral valve disease
  • Tendyne system
  • Transcatheter edge-to-edge repair
  • Transcatheter mitral valve replacement


Dive into the research topics of 'Characteristics and outcomes of patients undergoing transcatheter mitral valve replacement with the Tendyne system'. Together they form a unique fingerprint.

Cite this