Cell culture systems and drug targets for hepatitis a virus infection

Tatsuo Kanda; Reina Sasaki; Ryota Masuzaki; Naoki Matsumoto; Masahiro Ogawa; Mitsuhiko Moriyama

doi:10.3390/v12050533

Cell culture systems and drug targets for hepatitis a virus infection

Tatsuo Kanda, Reina Sasaki, Ryota Masuzaki, Naoki Matsumoto, Masahiro Ogawa, Mitsuhiko Moriyama

School of Medicine

Nihon University

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.

Original language	English
Article number	v12050533
Journal	Viruses
Volume	12
Issue number	5
DOIs	https://doi.org/10.3390/v12050533
Publication status	Published - May 2020

Keywords

50 UTR
Anti-HAV
Drug screening
HAV
Huh7
IRES
PLC/PRF/5
Subgenomic replicon
Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v12050533

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title = "Cell culture systems and drug targets for hepatitis a virus infection",

abstract = "Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.",

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T1 - Cell culture systems and drug targets for hepatitis a virus infection

AU - Kanda, Tatsuo

AU - Sasaki, Reina

AU - Masuzaki, Ryota

AU - Matsumoto, Naoki

AU - Ogawa, Masahiro

AU - Moriyama, Mitsuhiko

PY - 2020/5

Y1 - 2020/5

N2 - Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.

AB - Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.

KW - 50 UTR

KW - Anti-HAV

KW - Drug screening

KW - HAV

KW - Huh7

KW - IRES

KW - PLC/PRF/5

KW - Subgenomic replicon

KW - Vaccine

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U2 - 10.3390/v12050533

DO - 10.3390/v12050533

M3 - Review article

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SN - 1999-4915

VL - 12

JO - Viruses

JF - Viruses

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Cell culture systems and drug targets for hepatitis a virus infection

Abstract

Keywords

UN SDGs

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