Cell culture systems and drug targets for hepatitis a virus infection

Tatsuo Kanda, Reina Sasaki, Ryota Masuzaki, Naoki Matsumoto, Masahiro Ogawa, Mitsuhiko Moriyama

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.

Original languageEnglish
Article numberv12050533
JournalViruses
Volume12
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • 50 UTR
  • Anti-HAV
  • Drug screening
  • HAV
  • Huh7
  • IRES
  • PLC/PRF/5
  • Subgenomic replicon
  • Vaccine

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