Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review

Jun Kamei, Masafumi Kanamoto, Yutaka Igarashi, Kodai Suzuki, Kensuke Fujita, Tsukasa Kuwana, Takayuki Ogura, Katsunori Mochizuki, Yuki Banshotani, Hiroyasu Ishikura, Yoshihiko Nakamura

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Sepsis leads to organ dysfunction. Acute kidney injury, a common type of organ dysfunction, is associated with a high mortality rate in patients with sepsis. Kidney replacement therapy can correct the metabolic, electrolyte, and fluid imbalances caused by acute kidney injury. While this therapy can improve outcomes, evidence of its beneficial effects is lacking. Herein, we review the indications for blood purification therapy, including kidney replacement therapy, and the current knowledge regarding acute kidney injury in terms of renal and non-renal indications. While renal indications have been well-documented, indications for blood purification therapy in sepsis (non-renal indications) remain controversial. Excessive inflammation is an important factor in the development of sepsis; blood purification therapy has been shown to reduce inflammatory mediators and improve hemodynamic instability. Given the pathophysiology of sepsis, blood purification therapy may decrease mortality rates in these patients. Further trials are needed in order to establish the effectiveness of blood purification therapy for sepsis.

Original languageEnglish
Article number6388
JournalJournal of Clinical Medicine
Issue number19
Publication statusPublished - Oct 2023


  • acute kidney injury
  • kidney replacement therapy
  • non-renal indication
  • renal indication
  • sepsis


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