TY - JOUR
T1 - Autotaxin as a novel serum marker of liver fibrosis
AU - Nakagawa, Hayato
AU - Ikeda, Hitoshi
AU - Nakamura, Kazuhiro
AU - Ohkawa, Ryunosuke
AU - Masuzaki, Ryota
AU - Tateishi, Ryosuke
AU - Yoshida, Haruhiko
AU - Watanabe, Naoko
AU - Tejima, Kazuaki
AU - Kume, Yukio
AU - Iwai, Tomomi
AU - Suzuki, Atsushi
AU - Tomiya, Tomoaki
AU - Inoue, Yukiko
AU - Nishikawa, Takako
AU - Ohtomo, Natsuko
AU - Tanoue, Yasushi
AU - Omata, Masao
AU - Igarashi, Koji
AU - Aoki, Junken
AU - Koike, Kazuhiko
AU - Yatomi, Yutaka
PY - 2011/6/11
Y1 - 2011/6/11
N2 - Background: The clinical significance of autotaxin (ATX), a key enzyme for the production of the bioactive lysophospholipid lysophosphatidic acid remains unknown. Serum ATX enzymatic activity reportedly increases in parallel with liver fibrosis and exhibits a gender difference. Methods: Serum ATX antigen level, measured easier than the activity, was evaluated as a marker of liver fibrosis in 2 cohorts of chronic liver disease caused by hepatitis C virus. Results: In the first cohort, serum ATX level correlated significantly with liver fibrosis stage and was the best parameter for prediction of cirrhosis with an area under the receiver operating characteristic curve (AUROC) of 0.756 in male and 0.760 in female, when compared with serum hyaluronic acid and aminotransferase-to-platelet ratio index, an established marker of liver fibrosis. In another cohort, serum ATX level correlated significantly with liver stiffness, a novel reliable marker of liver fibrosis, being the second-best parameter in male (AUROC, 0.799) and in female (AUROC, 0.876) for prediction of significant fibrosis, and the best parameter in male (AUROC, 0.863) and the third-best parameter in female (AUROC, 0.872) for prediction of cirrhosis, both of which were judged by liver stiffness. Conclusions: Serum ATX level may be a novel marker of liver fibrosis.
AB - Background: The clinical significance of autotaxin (ATX), a key enzyme for the production of the bioactive lysophospholipid lysophosphatidic acid remains unknown. Serum ATX enzymatic activity reportedly increases in parallel with liver fibrosis and exhibits a gender difference. Methods: Serum ATX antigen level, measured easier than the activity, was evaluated as a marker of liver fibrosis in 2 cohorts of chronic liver disease caused by hepatitis C virus. Results: In the first cohort, serum ATX level correlated significantly with liver fibrosis stage and was the best parameter for prediction of cirrhosis with an area under the receiver operating characteristic curve (AUROC) of 0.756 in male and 0.760 in female, when compared with serum hyaluronic acid and aminotransferase-to-platelet ratio index, an established marker of liver fibrosis. In another cohort, serum ATX level correlated significantly with liver stiffness, a novel reliable marker of liver fibrosis, being the second-best parameter in male (AUROC, 0.799) and in female (AUROC, 0.876) for prediction of significant fibrosis, and the best parameter in male (AUROC, 0.863) and the third-best parameter in female (AUROC, 0.872) for prediction of cirrhosis, both of which were judged by liver stiffness. Conclusions: Serum ATX level may be a novel marker of liver fibrosis.
KW - Autotaxin
KW - Hyaluronic acid
KW - Liver fibrosis
KW - Liver stiffness
KW - Lysophosphatidic acid
KW - Lysophospholipase D
UR - http://www.scopus.com/inward/record.url?scp=79955483423&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2011.03.014
DO - 10.1016/j.cca.2011.03.014
M3 - Article
C2 - 21419756
AN - SCOPUS:79955483423
SN - 0009-8981
VL - 412
SP - 1201
EP - 1206
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 13-14
ER -
