Attenuation of naloxone-induced Vc pERK hyper-expression following capsaicin stimulation of the face in aged rat

Ikuko Suzuki; Junichi Kitagawa; Noboru Noma; Yoshiyuki Tsuboi; Masahiro Kondo; Kuniya Honda; Kenro Kanda; Momoko Hasegawa; Kazunobu Saito; Ryuzo Okamoto; Koichi Iwata

doi:10.1016/j.neulet.2008.07.003

Attenuation of naloxone-induced Vc pERK hyper-expression following capsaicin stimulation of the face in aged rat

Ikuko Suzuki, Junichi Kitagawa, Noboru Noma, Yoshiyuki Tsuboi, Masahiro Kondo, Kuniya Honda, Kenro Kanda, Momoko Hasegawa, Kazunobu Saito, Ryuzo Okamoto, Koichi Iwata

School of Dentistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In order to clarify the effect of age-related change in trigeminal nociception, phosphorylation of extracellular signal-regulated kinase (pERK) in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord neurons were studied in the aged rats following subcutaneous capsaicin injection into the whisker pad. A large number of pERK-LI cells was expressed in the superficial laminae of Vc and upper cervical spinal cord in adult and aged rats following subcutaneous capsaicin injection into the whisker pad region. The number of pERK-LI cells was largest at about 2.0 mm caudal from the obex and gradually decreased in their numbers in more rostral and caudal sections. The rostro-caudal distribution profile of pERK-LI cells expressed after subcutaneous capsaicin injection into whisker pad was similar in adult and aged rats. The number of pERK-LI cells was slightly, but not significantly larger in aged rats compared with that of adults. Pretreatment with naloxone significantly increased the number of capsaicin-induced pERK-LI cells in adult rats but not in aged rats. The present findings suggest that the descending modulation system impaired with advancing age, resulting in the abnormal pain sensation in aged rats.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Neuroscience Letters
Volume	442
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2008.07.003
Publication status	Published - 5 Sept 2008

Keywords

Aging
Capsaicin
Phosphorylation of extracellular signal-regulated kinase (pERK)
Trigeminal nerve
Trigeminal spinal subnucleus caudalis (Vc)

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10.1016/j.neulet.2008.07.003

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title = "Attenuation of naloxone-induced Vc pERK hyper-expression following capsaicin stimulation of the face in aged rat",

abstract = "In order to clarify the effect of age-related change in trigeminal nociception, phosphorylation of extracellular signal-regulated kinase (pERK) in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord neurons were studied in the aged rats following subcutaneous capsaicin injection into the whisker pad. A large number of pERK-LI cells was expressed in the superficial laminae of Vc and upper cervical spinal cord in adult and aged rats following subcutaneous capsaicin injection into the whisker pad region. The number of pERK-LI cells was largest at about 2.0 mm caudal from the obex and gradually decreased in their numbers in more rostral and caudal sections. The rostro-caudal distribution profile of pERK-LI cells expressed after subcutaneous capsaicin injection into whisker pad was similar in adult and aged rats. The number of pERK-LI cells was slightly, but not significantly larger in aged rats compared with that of adults. Pretreatment with naloxone significantly increased the number of capsaicin-induced pERK-LI cells in adult rats but not in aged rats. The present findings suggest that the descending modulation system impaired with advancing age, resulting in the abnormal pain sensation in aged rats.",

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author = "Ikuko Suzuki and Junichi Kitagawa and Noboru Noma and Yoshiyuki Tsuboi and Masahiro Kondo and Kuniya Honda and Kenro Kanda and Momoko Hasegawa and Kazunobu Saito and Ryuzo Okamoto and Koichi Iwata",

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AU - Suzuki, Ikuko

AU - Kitagawa, Junichi

AU - Noma, Noboru

AU - Tsuboi, Yoshiyuki

AU - Kondo, Masahiro

AU - Honda, Kuniya

AU - Kanda, Kenro

AU - Hasegawa, Momoko

AU - Saito, Kazunobu

AU - Okamoto, Ryuzo

AU - Iwata, Koichi

PY - 2008/9/5

Y1 - 2008/9/5

N2 - In order to clarify the effect of age-related change in trigeminal nociception, phosphorylation of extracellular signal-regulated kinase (pERK) in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord neurons were studied in the aged rats following subcutaneous capsaicin injection into the whisker pad. A large number of pERK-LI cells was expressed in the superficial laminae of Vc and upper cervical spinal cord in adult and aged rats following subcutaneous capsaicin injection into the whisker pad region. The number of pERK-LI cells was largest at about 2.0 mm caudal from the obex and gradually decreased in their numbers in more rostral and caudal sections. The rostro-caudal distribution profile of pERK-LI cells expressed after subcutaneous capsaicin injection into whisker pad was similar in adult and aged rats. The number of pERK-LI cells was slightly, but not significantly larger in aged rats compared with that of adults. Pretreatment with naloxone significantly increased the number of capsaicin-induced pERK-LI cells in adult rats but not in aged rats. The present findings suggest that the descending modulation system impaired with advancing age, resulting in the abnormal pain sensation in aged rats.

AB - In order to clarify the effect of age-related change in trigeminal nociception, phosphorylation of extracellular signal-regulated kinase (pERK) in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord neurons were studied in the aged rats following subcutaneous capsaicin injection into the whisker pad. A large number of pERK-LI cells was expressed in the superficial laminae of Vc and upper cervical spinal cord in adult and aged rats following subcutaneous capsaicin injection into the whisker pad region. The number of pERK-LI cells was largest at about 2.0 mm caudal from the obex and gradually decreased in their numbers in more rostral and caudal sections. The rostro-caudal distribution profile of pERK-LI cells expressed after subcutaneous capsaicin injection into whisker pad was similar in adult and aged rats. The number of pERK-LI cells was slightly, but not significantly larger in aged rats compared with that of adults. Pretreatment with naloxone significantly increased the number of capsaicin-induced pERK-LI cells in adult rats but not in aged rats. The present findings suggest that the descending modulation system impaired with advancing age, resulting in the abnormal pain sensation in aged rats.

KW - Aging

KW - Capsaicin

KW - Phosphorylation of extracellular signal-regulated kinase (pERK)

KW - Trigeminal nerve

KW - Trigeminal spinal subnucleus caudalis (Vc)

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ER -

Attenuation of naloxone-induced Vc pERK hyper-expression following capsaicin stimulation of the face in aged rat

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Keywords

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