TY - JOUR
T1 - Atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium X-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation
AU - Yamamichi, Nobutake
AU - Hirano, Chigaya
AU - Ichinose, Masao
AU - Takahashi, Yu
AU - Minatsuki, Chihiro
AU - Matsuda, Rie
AU - Nakayama, Chiemi
AU - Shimamoto, Takeshi
AU - Kodashima, Shinya
AU - Ono, Satoshi
AU - Tsuji, Yosuke
AU - Niimi, Keiko
AU - Sakaguchi, Yoshiki
AU - Kataoka, Yosuke
AU - Saito, Itaru
AU - Asada-Hirayama, Itsuko
AU - Takeuchi, Chihiro
AU - Yakabi, Seiichi
AU - Kaikimoto, Hikaru
AU - Matsumoto, Yuta
AU - Yamaguchi, Daisuke
AU - Kageyama-Yahara, Natsuko
AU - Fujishiro, Mitsuhiro
AU - Wada, Ryoichi
AU - Mitsushima, Toru
AU - Koike, Kazuhiko
N1 - Publisher Copyright:
© 2015, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is the standard gastric cancer screening method in Japan. Atrophic gastritis and enlarged gastric folds are considered the two major features of Helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by UGI-XR has not been elucidated. Methods: We analyzed healthy UGI-XR examinees without a history of gastrectomy, previous Helicobacter pylori eradication and usage of gastric acid suppressants. Results and conclusions: Of the 6433 subjects, 1936 (30.1 %) had atrophic gastritis and 1253 (19.5 %) had enlarged gastric folds. During the 3-year prospective observational follow-up, gastric cancer developed in seven subjects, six of whom (85.7 %) had atrophic gastritis with H. pylori infection and five of whom (71.4 %) had enlarged gastric folds with H. pylori infection. The Kaplan-Meier method with log-rank testing revealed that both UGI-XR-based atrophic gastritis (p = 0.0011) and enlarged gastric folds (p = 0.0003) are significant predictors for future gastric cancer incidence.
AB - Background: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is the standard gastric cancer screening method in Japan. Atrophic gastritis and enlarged gastric folds are considered the two major features of Helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by UGI-XR has not been elucidated. Methods: We analyzed healthy UGI-XR examinees without a history of gastrectomy, previous Helicobacter pylori eradication and usage of gastric acid suppressants. Results and conclusions: Of the 6433 subjects, 1936 (30.1 %) had atrophic gastritis and 1253 (19.5 %) had enlarged gastric folds. During the 3-year prospective observational follow-up, gastric cancer developed in seven subjects, six of whom (85.7 %) had atrophic gastritis with H. pylori infection and five of whom (71.4 %) had enlarged gastric folds with H. pylori infection. The Kaplan-Meier method with log-rank testing revealed that both UGI-XR-based atrophic gastritis (p = 0.0011) and enlarged gastric folds (p = 0.0003) are significant predictors for future gastric cancer incidence.
KW - Atrophic gastritis
KW - Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR)
KW - Enlarged gastric folds
KW - Gastric cancer
KW - Helicobacter pylori
UR - http://www.scopus.com/inward/record.url?scp=84944930442&partnerID=8YFLogxK
U2 - 10.1007/s10120-015-0558-0
DO - 10.1007/s10120-015-0558-0
M3 - Article
C2 - 26486508
AN - SCOPUS:84944930442
SN - 1436-3291
VL - 19
SP - 1016
EP - 1022
JO - Gastric Cancer
JF - Gastric Cancer
IS - 3
ER -
