TY - CHAP
T1 - Application of peripheral near infrared spectroscopy to assess risk factors in patient with coronary artery disease
T2 - Part 1
AU - Kawamorita, Tsuyoshi
AU - Kuronuma, Keiichiro
AU - Yagi, Tsukasa
AU - Tachibana, Eizo
AU - Sugai, Shonosuke
AU - Hayashida, Satoshi
AU - Iso, Kazuki
AU - Iida, Korehito
AU - Atsumi, Wataru
AU - Kunimoto, Satoshi
AU - Suzuki, Yasuyuki
AU - Tani, Shigemasa
AU - Matsumoto, Naoya
AU - Okumura, Yasuo
AU - Sakatani, Kaoru
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2020.
PY - 2020
Y1 - 2020
N2 - Obesity, a risk factor of coronary artery disease, is known to cause peripheral microcirculatory disturbances. This study evaluated the relationship between the degree of obesity and peripheral microcirculatory disturbances, using peripheral near infrared spectroscopy (NIRS) with a vascular occlusion test (VOT). We compared correlations between the NIRS parameter changes induced by VOT and body mass index (BMI) in patients with and without statin therapy. A NIRS probe was set on the right thenar eminence, brachial artery blood flow was blocked for 3 min, and then released. Although total hemoglobin (ΔcHb), deoxyhemoglobin (ΔHHb) and tissue oxygenation index (ΔTOI) were not correlated with BMI, a significant negative correlation was found between oxyhemoglobin (ΔO2Hb) and BMI in the overall study population (r = −0.255, p-value 0.02). In addition, a significant negative correlation was found between ΔO2Hb and BMI in patients without statin therapy (r = −0.353, p-value 0.02) but not in patients with statin therapy (r = −0.181, p-value 0.27). These findings suggest that ΔO2Hb may be a useful indicator to assess peripheral microcirculation.
AB - Obesity, a risk factor of coronary artery disease, is known to cause peripheral microcirculatory disturbances. This study evaluated the relationship between the degree of obesity and peripheral microcirculatory disturbances, using peripheral near infrared spectroscopy (NIRS) with a vascular occlusion test (VOT). We compared correlations between the NIRS parameter changes induced by VOT and body mass index (BMI) in patients with and without statin therapy. A NIRS probe was set on the right thenar eminence, brachial artery blood flow was blocked for 3 min, and then released. Although total hemoglobin (ΔcHb), deoxyhemoglobin (ΔHHb) and tissue oxygenation index (ΔTOI) were not correlated with BMI, a significant negative correlation was found between oxyhemoglobin (ΔO2Hb) and BMI in the overall study population (r = −0.255, p-value 0.02). In addition, a significant negative correlation was found between ΔO2Hb and BMI in patients without statin therapy (r = −0.353, p-value 0.02) but not in patients with statin therapy (r = −0.181, p-value 0.27). These findings suggest that ΔO2Hb may be a useful indicator to assess peripheral microcirculation.
KW - Coronary artery disease
KW - Microcirculation
KW - Near infrared spectroscopy
KW - Obesity
KW - Vascular occlusion test
UR - http://www.scopus.com/inward/record.url?scp=85077454747&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-34461-0_42
DO - 10.1007/978-3-030-34461-0_42
M3 - Chapter
C2 - 31893428
AN - SCOPUS:85077454747
T3 - Advances in Experimental Medicine and Biology
SP - 331
EP - 337
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
