Application of peripheral near infrared spectroscopy to assess risk factors in patient with coronary artery disease: Part 2

Keiichiro Kuronuma, Tsuyoshi Kawamorita, Tsukasa Yagi, Eizo Tachibana, Shonosuke Sugai, Satoshi Hayashida, Kazuki Iso, Korehito Iida, Wataru Atsumi, Satoshi Kunimoto, Yasuyuki Suzuki, Shigemasa Tani, Naoya Matsumoto, Yasuo Okumura, Kaoru Sakatani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


Epicardial adipose tissue (EAT) is associated with visceral fat and various cardiac disorders, such as atrial fibrillation and adverse cardiovascular events. Therefore, it is important to develop a simple and non-invasive inspection method to assess EAT, to prevent unfavorable cardiac events. This study assessed correlations between near-infrared spectroscopy (NIRS) changes induced by a vascular occlusion test (VOT) and EAT volume measured by cardiac computed tomography (CCT) in patients with suspected coronary artery disease. We also assessed correlations between body mass index (BMI) and EAT volume in the same population. In addition, these correlations were compared in patients treated with statin therapy and in those without statin therapy. A NIRS probe was set on the right thenar eminence, and brachial artery blood flow was blocked for 3 min before being released. A negative correlation was found between oxyhemoglobin (ΔO2Hb) and EAT volume in the overall study population (r = −0.236, p = 0.03). Interestingly, although a strong correlation was observed in patients without statin therapy (r = −0.488, p < 0.001), this correlation was not observed in patients with statin therapy (r = 0.157, p = 0.34). These findings suggest that NIRS measurements with VOT may be a useful method to identify patients with high EAT volume and high cardiovascular risks.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages6
Publication statusPublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cardiac computed tomography
  • Epicardial adipose tissue
  • Microcirculation
  • Near infrared spectroscopy
  • Vascular occlusion test


Dive into the research topics of 'Application of peripheral near infrared spectroscopy to assess risk factors in patient with coronary artery disease: Part 2'. Together they form a unique fingerprint.

Cite this