Affinity for music in wolf-hirschhorn syndrome: Two case reports

Chikako Arakawa, Yukihiko Fujita, Tatsuo Fuchigami, Yuki Kawamura, Wakako Ishii, Ayumi Endo, Ryutaro Kohira, Shori Takahashi

Research output: Contribution to journalArticlepeer-review


Background Wolf-Hirschhorn syndrome is a congenital malformation syndrome resulting from deletion of the short arm of chromosome 4. Individuals with Wolf-Hirschhorn syndrome may have a "Greek warrior helmet" appearance, growth retardation, developmental delay, muscular hypotonia, epilepsy, and difficulty with language including verbal communication. An affinity for music has not previously been reported in these patients.

Patients We describe two patients with Wolf-Hirschhorn syndrome who both have a strong affinity for music. One patient is a 20-year-old woman who likes to listen to music all day and can hum many tunes. The other patient is a 9-year-old girl who is calmed by music and received music therapy, with subsequent improvement in her communication skills (eye contact, joint attention, and vocalizations to request music).

Conclusions Individuals with Wolf-Hirschhorn syndrome may have a strong affinity for music and may benefit from music therapy. Additional studies are needed to investigate the interest in music in individuals with Wolf-Hirschhorn syndrome.

Original languageEnglish
Pages (from-to)550-552
Number of pages3
JournalPediatric Neurology
Issue number4
Publication statusPublished - 1 Oct 2014


  • Wolf-Hirschhorn syndrome
  • chromosomal disorder
  • communication skills
  • music
  • music therapy


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