TY - JOUR
T1 - A case of mycobacterium abscessus pulmonary infection
T2 - Effects of clarithromycin, ethambutol, and rifampicin therapy
AU - Sekiyama, Tadataka
AU - Suguro, Hajime
AU - Ooki, Takashi
AU - Nakao, Yuta
AU - Satou, Yoshihiro
AU - Takano, Yuki
AU - Suzuki, Mamiko
AU - Ishiwatarai, Yusaku
AU - Kogawa, Noriko
AU - Hataoka, Tsukasa
AU - Hayashi, Kentaro
AU - Igei, Koumei
AU - Okamoto, Naoki
AU - Hattori, Tomohiro
AU - Takahashi, Noriaki
AU - Hashimoto, Shu
PY - 2013
Y1 - 2013
N2 - A 71-year-old woman presented with a persistent cough. Her chest X-ray film showed an infiltrative and granular shadow in the left upper lobe and S 6 regions. Staining of sputum and bronchus lavage smears revealed the presence of acid-fast bacilli. The patient was first treated with clarithromycin, amikacin, and imipenem/cilastatin. Chemotherapy was discontinued in the patient because the drugs induced skin eruptions. After an improvement in the skin condition, the patient was treated with clarithromycin, ethambutol, and rifampicin for 12 months, during which the chest radiography and computed tomography (CT) results revealed improvements. The patients symptoms and radiographic findings improved following chemotherapy, and were reflected in her sputum test results. However, Mycobacterium abscessus was completely resistant to treatment with all the anti-tuberculosis agents. Thus, the results obtained by drug sensitivity testing of the antibiotics did not correlate with the clinical outcomes, indicating that drug testing may not necessarily be predictive of the therapeutic outcome.
AB - A 71-year-old woman presented with a persistent cough. Her chest X-ray film showed an infiltrative and granular shadow in the left upper lobe and S 6 regions. Staining of sputum and bronchus lavage smears revealed the presence of acid-fast bacilli. The patient was first treated with clarithromycin, amikacin, and imipenem/cilastatin. Chemotherapy was discontinued in the patient because the drugs induced skin eruptions. After an improvement in the skin condition, the patient was treated with clarithromycin, ethambutol, and rifampicin for 12 months, during which the chest radiography and computed tomography (CT) results revealed improvements. The patients symptoms and radiographic findings improved following chemotherapy, and were reflected in her sputum test results. However, Mycobacterium abscessus was completely resistant to treatment with all the anti-tuberculosis agents. Thus, the results obtained by drug sensitivity testing of the antibiotics did not correlate with the clinical outcomes, indicating that drug testing may not necessarily be predictive of the therapeutic outcome.
KW - Drug sensitivity testing
KW - Mycobacterium abscessus
KW - Non-tuberculous mycobacteria
UR - http://www.scopus.com/inward/record.url?scp=84892142699&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84892142699
SN - 0385-3667
VL - 72
SP - 1380
EP - 1385
JO - Japanese Journal of Chest Diseases
JF - Japanese Journal of Chest Diseases
IS - 12
ER -
