TY - JOUR
T1 - 肝 mixed neuroendocrine-non-neuroendocrine neoplasm の 3 切除例
AU - Toyonaka, Ryosuke
AU - Aramaki, Osamu
AU - Yoshida, Nao
AU - Mitsuka, Yusuke
AU - Nakamura, Masanori
AU - Inagaki, Shu
AU - Murai, Kaiki
AU - Ishige, Toshiyuki
AU - Tsujimura, Ryusuke
AU - Ohni, Sumie
AU - Masuda, Shinobu
AU - Yamashita, Hiroharu
AU - Okamura, Yukiyasu
N1 - Publisher Copyright:
© 2025 The Japanese Society of Gastroenterological Surgery.
PY - 2025
Y1 - 2025
N2 - Case 1: A 71-year-old man was diagnosed with S8 hepatocellular carcinoma (HCC) and underwent surgery. Histopathological examination revealed that the tumor was a mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). Three months after surgery, multiple intrahepatic recurrences were identified and the patient was treated with transcatheter arterial chemoembolization (TACE). Eleven months after surgery, thoracic spinal metastasis occurred, and the patient died 13 months after surgery. Case 2: A 73-year-old man was diagnosed with S7 HCC and underwent surgery. Histopathological examination revealed MiNEN. Two months after surgery, adrenal and peritoneal metastasis occurred. The patient received systemic chemotherapy, but died 16 months after surgery. Case 3: A 77-year-old woman was diagnosed with S4 HCC and underwent surgery. Histopathological examination revealed MiNEN. Three months after surgery, there were multiple intrahepatic recurrences, peritoneal dissemination, and lymph node recurrences. The patient received systemic chemotherapy, but died six months after surgery. We report three surgical cases of primary hepatic MiNEN in which preoperative diagnosis was difficult. Primary hepatic MiNEN has an extremely poor prognosis and is resistant to conventional multidisciplinary therapies, including surgery, TACE, and systemic chemotherapy.
AB - Case 1: A 71-year-old man was diagnosed with S8 hepatocellular carcinoma (HCC) and underwent surgery. Histopathological examination revealed that the tumor was a mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). Three months after surgery, multiple intrahepatic recurrences were identified and the patient was treated with transcatheter arterial chemoembolization (TACE). Eleven months after surgery, thoracic spinal metastasis occurred, and the patient died 13 months after surgery. Case 2: A 73-year-old man was diagnosed with S7 HCC and underwent surgery. Histopathological examination revealed MiNEN. Two months after surgery, adrenal and peritoneal metastasis occurred. The patient received systemic chemotherapy, but died 16 months after surgery. Case 3: A 77-year-old woman was diagnosed with S4 HCC and underwent surgery. Histopathological examination revealed MiNEN. Three months after surgery, there were multiple intrahepatic recurrences, peritoneal dissemination, and lymph node recurrences. The patient received systemic chemotherapy, but died six months after surgery. We report three surgical cases of primary hepatic MiNEN in which preoperative diagnosis was difficult. Primary hepatic MiNEN has an extremely poor prognosis and is resistant to conventional multidisciplinary therapies, including surgery, TACE, and systemic chemotherapy.
KW - extrahepatic recurrence
KW - mixed neuroendocrine-non-neuroendocrine neoplasm
KW - primary hepatic tumor
UR - https://www.scopus.com/pages/publications/105009863297
U2 - 10.5833/jjgs.2024.0058
DO - 10.5833/jjgs.2024.0058
M3 - 記事
AN - SCOPUS:105009863297
SN - 0386-9768
VL - 58
SP - 331
EP - 343
JO - Japanese Journal of Gastroenterological Surgery
JF - Japanese Journal of Gastroenterological Surgery
IS - 6
ER -